Clinical characteristics of dome-shaped macula in mild myopic or non-myopic eyes.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY Eye Pub Date : 2025-03-17 DOI:10.1038/s41433-025-03756-8

Mengyang Li, Zhi Li, Fei Xiang, Caixia Li, Ye Zhang, Shuning Li

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Abstract

Objectives: To investigate dome-shaped macula (DSM) in mild myopic or non-myopic eyes.

Methods: Participants aged 50 years or older were recruited from July 2023 to August 2023. Clinical features including age, sex, visual acuity (VA), spherical equivalent refraction (SER), ocular biometry parameters, SS-OCT parameters and macular complications were compared between eyes with and without DSM. Logistic analysis was performed to explore risk factors for DSM.

Results: 923 eyes were enrolled in the final analysis. The overall prevalence of DSM was 3.03% (28/923). Among eyes with DSM, 13 eyes (46.4%) were emmetropia, 9 eyes (32.1%) were hypermetropia, and 6 eyes (21.4%) were myopia, with 4 eyes (14.3%) were mild myopia and one eye (3.6%) was moderate myopia. The mean subfoveal choroidal thickness (SFCT) in eyes with DSM was 168.00 ± 77.79μm, which was significantly thinner than their counterparts absent of DSM (289.11 ± 95.58μm, p < 0.001). Logistic regression revealed that longer AL (odds ratio (OR) = 1.716, 95%CI: 1.205-2.442, p = 0.003) and female sex (OR = 3.330, 95% CI: 1.109-10.005, p = 0.032) were associated with DSM. No vitreomacular complication including epiretinal membrane (ERM), vitreomacular traction (VMT), lamellar macular hole (LMH) and full-thickness macular hole (FTMH) was found in eyes with DSM, while the overall prevalence of those macular complications in eye without DSM was 8.8% (79/895).

Conclusions: The study offered a detailed profile of DSM in mild myopic or non-myopic eyes and found a diffuse thinning of choroid in both foveal and parafoveal area in eyes with DSM. No case with vitreomacular complications was identified in DSM eyes in our study population.

Trail registration: The registration number of the present trial in the Chinese Clinical Trial Registry is ChiCTR2000037944.

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.