Pub Date : 2026-01-14DOI: 10.1038/s41433-025-04195-1
Maria S Varughese, Ananth U Nayak, Lakshminarayanan Varadhan
{"title":"Comment on: 'Thyroid eye disease and steroid therapy: risk stratification for bone health'.","authors":"Maria S Varughese, Ananth U Nayak, Lakshminarayanan Varadhan","doi":"10.1038/s41433-025-04195-1","DOIUrl":"https://doi.org/10.1038/s41433-025-04195-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1038/s41433-026-04239-0
Mª Carmen García Cruz, Ana Flores Márquez, Ana Morilla Ortega, Juan Ángel Moreno Gutiérrez, Marina Barranco Rodríguez, José Escarramán Reyes, Natalia García Casares, Ana Chinchurreta Capote
{"title":"Resilience and vision-related quality of life in advanced age-related macular degeneration: a brief clinical report.","authors":"Mª Carmen García Cruz, Ana Flores Márquez, Ana Morilla Ortega, Juan Ángel Moreno Gutiérrez, Marina Barranco Rodríguez, José Escarramán Reyes, Natalia García Casares, Ana Chinchurreta Capote","doi":"10.1038/s41433-026-04239-0","DOIUrl":"https://doi.org/10.1038/s41433-026-04239-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1038/s41433-025-04234-x
Zhihao Lei
{"title":"\"Overfitting or insight?\" Re-evaluating a blood-based machine learning model for high myopia.","authors":"Zhihao Lei","doi":"10.1038/s41433-025-04234-x","DOIUrl":"https://doi.org/10.1038/s41433-025-04234-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1038/s41433-025-04215-0
Lee Jones, Dominic H Ffytche, Mariya Moosajee
{"title":"Management of Charles Bonnet syndrome in routine eye care services.","authors":"Lee Jones, Dominic H Ffytche, Mariya Moosajee","doi":"10.1038/s41433-025-04215-0","DOIUrl":"https://doi.org/10.1038/s41433-025-04215-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1038/s41433-025-04236-9
Emmanuel Pio Pastore
{"title":"Calibrated AI for nAMD monitoring with transport validation and actionable thresholds.","authors":"Emmanuel Pio Pastore","doi":"10.1038/s41433-025-04236-9","DOIUrl":"https://doi.org/10.1038/s41433-025-04236-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1038/s41433-025-04223-0
Fatma F Shakarchi, Ahmed F Shakarchi, Ahmed B Sallam
{"title":"Punctate Inner Retinal Toxoplasmosis (PIRT): Multimodal Imaging.","authors":"Fatma F Shakarchi, Ahmed F Shakarchi, Ahmed B Sallam","doi":"10.1038/s41433-025-04223-0","DOIUrl":"https://doi.org/10.1038/s41433-025-04223-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1038/s41433-025-04203-4
Tengbo Rao, Jiarui Yang, Yanfeng Liao, Yi Ding, Yiwen Shi, Huijin Chen, Xuemin Li
Purpose: This study investigates changes in vascular and stromal components of choroidal vascular layers using ultra-widefield optical coherence tomography angiography (OCTA).
Methods: A cross-sectional study included 147 participants with varying myopia degrees, categorised as low myopia (70 eyes), moderate myopia (104 eyes), and high myopia (110 eyes) based on refractive status. The TowardPi Wide-field OCTA measured choroidal parameters, including thickness, choriocapillaris density, vascular volume, and stromal volume. Differences in these parameters were analysed among the three myopia groups.
Results: Choroidal thickness decreased with increasing myopia, notably at the sub-fovea (LM vs MM vs HM: 297.56 ± 83.19 μm vs 230.13 ± 77.35 μm vs 190.49 ± 70.24 μm, P < 0.001) and macular region (258.20 ± 67.40 μm vs 215.37 ± 56.07 μm vs 186.01 ± 49.10 μm, P < 0.001). Choriocapillaris density in the macular region increased with myopia severity (48.06 ± 1.36% vs 48.15 ± 0.99% vs 48.74 ± 1.11%, P < 0.001). Vascular volume declined most in the macular (LM vs MM: 5.98 ± 1.62 mm³ vs 4.21 ± 1.52 mm³, P < 0.001). Stromal volume changes were prominent between moderate and high myopia (MM vs HM: 6.59 ± 1.48 mm³ vs 6.12 ± 0.75 mm³, P < 0.001). Axial length correlated with stromal volume (R = -0.498, P < 0.001), while spherical equivalent correlated with choroidal volume (R = 0.474, P < 0.001).
Conclusion: Wide-field OCTA effectively highlights choroidal component changes associated with myopia severity, offering insights into its structural alterations.
目的：利用超宽视场光学相干断层血管成像（OCTA）研究脉络膜血管层血管和基质成分的变化。方法：一项横断面研究包括147名不同近视程度的参与者，根据屈光状态分为低近视（70眼）、中度近视（104眼）和高度近视（110眼）。TowardPi宽视场OCTA测量脉络膜参数，包括厚度、脉络膜毛细血管密度、血管体积和间质体积。分析三个近视组在这些参数上的差异。结果：随着近视程度的增加，脉络膜厚度下降，特别是在中央凹下（LM vs MM vs HM: 297.56±83.19 μm vs 230.13±77.35 μm vs 190.49±70.24 μm）。结论：广角OCTA有效地显示了与近视严重程度相关的脉络膜成分变化，为其结构变化提供了新的视角。
{"title":"Investigation of 3D choroidal components in myopic populations using ultra-widefield OCTA.","authors":"Tengbo Rao, Jiarui Yang, Yanfeng Liao, Yi Ding, Yiwen Shi, Huijin Chen, Xuemin Li","doi":"10.1038/s41433-025-04203-4","DOIUrl":"https://doi.org/10.1038/s41433-025-04203-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates changes in vascular and stromal components of choroidal vascular layers using ultra-widefield optical coherence tomography angiography (OCTA).</p><p><strong>Methods: </strong>A cross-sectional study included 147 participants with varying myopia degrees, categorised as low myopia (70 eyes), moderate myopia (104 eyes), and high myopia (110 eyes) based on refractive status. The TowardPi Wide-field OCTA measured choroidal parameters, including thickness, choriocapillaris density, vascular volume, and stromal volume. Differences in these parameters were analysed among the three myopia groups.</p><p><strong>Results: </strong>Choroidal thickness decreased with increasing myopia, notably at the sub-fovea (LM vs MM vs HM: 297.56 ± 83.19 μm vs 230.13 ± 77.35 μm vs 190.49 ± 70.24 μm, P < 0.001) and macular region (258.20 ± 67.40 μm vs 215.37 ± 56.07 μm vs 186.01 ± 49.10 μm, P < 0.001). Choriocapillaris density in the macular region increased with myopia severity (48.06 ± 1.36% vs 48.15 ± 0.99% vs 48.74 ± 1.11%, P < 0.001). Vascular volume declined most in the macular (LM vs MM: 5.98 ± 1.62 mm³ vs 4.21 ± 1.52 mm³, P < 0.001). Stromal volume changes were prominent between moderate and high myopia (MM vs HM: 6.59 ± 1.48 mm³ vs 6.12 ± 0.75 mm³, P < 0.001). Axial length correlated with stromal volume (R = -0.498, P < 0.001), while spherical equivalent correlated with choroidal volume (R = 0.474, P < 0.001).</p><p><strong>Conclusion: </strong>Wide-field OCTA effectively highlights choroidal component changes associated with myopia severity, offering insights into its structural alterations.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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