Muhammad Danish Mujib, Ahmad Zahid Rao, Muhammad Fahim Ul Haque, Ahmad O Alokaily, Syeda Sehar Hussain, Ahmed A Aldohbayb, Saad Ahmed Qazi, Muhammad Abul Hasan
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引用次数: 0
Abstract
Introduction: Alzheimer's disease (AD) affects 50 million individuals worldwide, a number projected to triple by 2050. Due to discomfort through electrical and magnetic neuromodulation technologies, this is the first study to propose the potential of auditory binaural beat (BB) stimulation at an alpha frequency (10 Hz) for enhancing cognitive and neurological outcomes in AD patients.
Methods: Twenty-five patients were divided into the experimental-Group (n = 15) and control-Group (n = 10). Psychometric and neurological assessments were conducted Pre-Treatment (Day 1) and Post-Treatment (Day 14) following consecutive days of binaural beats (BB) or auditory tone stimulation administered from Day 2 to Day 13.
Results: A two-way ANOVA revealed a significant main effect of group (F = 6.087, p = 0.016) and session (F = 3.859, p = 0.024) on MMSE scores, with the experimental group showing significant improvement in MMSE scores (t = 7.33, p = 0.00000012) compared to the control group (p = 0.2306). Paired t-tests revealed a significant reduction in depression scores (DASS-21, t = 1.701, p = 0.0253) in the experimental group, while no significant improvements were noted in the control group. EEG recordings revealed significant changes in α-band, β-band, and γ-band power (p < 0.05). Moreover, The correlation between EEG bands and MMSE subparts showed that increased θ-band power in the experimental group was positively correlated (p < 0.05) with the frontal region during language tasks and in the frontal and central regions during registration and orientation tasks, indicating potential neurocognitive benefits.
Discussion: The results of this research imply that BB stimulation has untapped potential as a non-invasive therapy for patients with AD, hence there is the need for further studies to manage the dementia epidemic.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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