Diagnostic efficacy of soluble ST2 in pediatric fulminant myocarditis.

IF 2 3区医学 Q2 PEDIATRICS Frontiers in Pediatrics Pub Date : 2025-03-03 eCollection Date: 2025-01-01 DOI:10.3389/fped.2025.1417341

YanZhu Huang, YiHu Lin, MingHong Fu, WeiFeng Zhang

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Abstract

Background and aims: Early identification of fulminant myocarditis (FM) is the key to reducing mortality, but there is still a lack of effective biomarkers for diagnosis. The aim of this study was to investigate the value of soluble ST2 (sST2) in identifying FM in children.

Methods: This was a single-center clinical observational study. We consecutively enrolled 144 children younger than 14 years of age diagnosed with viral myocarditis between January 2018 and November 2023, of whom 63 were diagnosed with FM.

Results: The sST2 level in the FM group was significantly higher than that in the non-FM group [104.40 (68.80, 150.10) vs. 38.30 (19.85, 55.05), p < 0.001]. ROC curves showed that the optimal cut-off values of sST2, TNI, NT-proBNP and CRP for FM were 63.8 ng/ml, 13.3 ng/ml, 3182 pg/ml and 26.5 mg/L, respectively. The sensitivity and specificity of sST2 were 84.13% and 88.9%, indicating the highest early diagnosis efficiency. Multifactorial correction showed that sST2 ≥ 63.8 ng/ml and NT-proBNP ≥ 3182 pg/ml were independent diagnostic predictors of FM (OR = 22.374, 95% CI: 8.140 ∼ 61.499, P < 0.001), and (OR = 3.208, 95% CI: 1.163 ∼ 8.846, P = 0.024).

Conclusions: With high sensitivity and specificity, sST2 may serve as a strong predictor of pediatric FM.

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可溶性ST2在小儿暴发性心肌炎中的诊断价值。

背景与目的：早期识别暴发性心肌炎（FM）是降低死亡率的关键，但目前仍缺乏有效的诊断生物标志物。本研究的目的是探讨可溶性ST2 （sST2）在鉴别儿童FM中的价值。方法：本研究为单中心临床观察性研究。我们在2018年1月至2023年11月期间连续招募了144名14岁以下诊断为病毒性心肌炎的儿童，其中63名诊断为FM。结果：FM组sST2水平显著高于非FM组[104.40（68.80,150.10）比38.30 (19.85,55.05),p p p = 0.024]。结论：sST2具有较高的敏感性和特异性，可能是儿童FM的重要预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.