Oral ulcers in hematological malignancy patients undergoing chemotherapy: is it chemotherapy or neutropenia?: a case report and review of the literature.
Fatima AlZahraa Al Beesh, Nafiza Martini, Siham Suleiman, Abeer Aljoujou
{"title":"Oral ulcers in hematological malignancy patients undergoing chemotherapy: is it chemotherapy or neutropenia?: a case report and review of the literature.","authors":"Fatima AlZahraa Al Beesh, Nafiza Martini, Siham Suleiman, Abeer Aljoujou","doi":"10.1186/s13256-025-05180-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy can cause oral complications either directly, by inducing mucosal degeneration, or indirectly, through myelosuppression leading to neutropenia. Neutropenia, a common side effect, is often associated with multiple oral ulcers.</p><p><strong>Case presentation: </strong>A 39-year-old Arabic Syrian man with acute myelogenous leukemia developed neutropenia following his initial chemotherapy course, resulting in oral ulcers. A complete blood count confirmed chemotherapy-induced neutropenia, and the clinical presentation supported the diagnosis of neutropenic ulcers. The patient's chemotherapy regimen was temporarily halted, and a topical corticosteroid paste containing triamcinolone acetonide was applied three times daily for 7 days. This treatment led to significant regression of the ulcers. The patient provided written informed consent after receiving a detailed explanation of the study's objectives, procedures, and privacy considerations.</p><p><strong>Conclusion: </strong>Topical corticosteroid treatment effectively promoted significant regression of neutropenic ulcers in this case.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"119"},"PeriodicalIF":0.8000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916965/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13256-025-05180-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Chemotherapy can cause oral complications either directly, by inducing mucosal degeneration, or indirectly, through myelosuppression leading to neutropenia. Neutropenia, a common side effect, is often associated with multiple oral ulcers.
Case presentation: A 39-year-old Arabic Syrian man with acute myelogenous leukemia developed neutropenia following his initial chemotherapy course, resulting in oral ulcers. A complete blood count confirmed chemotherapy-induced neutropenia, and the clinical presentation supported the diagnosis of neutropenic ulcers. The patient's chemotherapy regimen was temporarily halted, and a topical corticosteroid paste containing triamcinolone acetonide was applied three times daily for 7 days. This treatment led to significant regression of the ulcers. The patient provided written informed consent after receiving a detailed explanation of the study's objectives, procedures, and privacy considerations.
Conclusion: Topical corticosteroid treatment effectively promoted significant regression of neutropenic ulcers in this case.
期刊介绍：
JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
