Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice.

Abstract

Background: The Commiphora gileadensis (C. gileadensis) is a tree belonging to the genus Commiphora. Aim of the study: This study investigates the effect of C. gileadensis on erectile dysfunction and infertility in male mice.

Methods: Fifty male BALB/c mice are divided into five groups: control, untreated diabetic, diabetic C. gileadensis sap-treated, methanol extract-treated, and acetone extract-treated. All groups were assessed for body weight, testicular weight, serum follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin, nitric oxide, adropin, endothelin levels, semen analysis, CD4⁺, CD8⁺, CD25⁺, and testicular nitric oxide synthase (NOS) immunoreactivity.

Outcome: C. gileadensis maintains sexual integrity and infertility in mice.

Results: Diabetic groups treated with C. gileadensis had significantly higher body weight than the untreated group. Furthermore, the diabetic group treated with C. gileadensis sap had significantly increased testicular weight than the untreated groups. Diabetic groups treated with C. gileadensis had significantly greater testosterone levels than the untreated groups. Additionally, these groups exhibit considerably higher nitric oxide and adropin levels than the untreated diabetic group. Endothelin levels were considerably lower in diabetic groups treated with C. gileadensis than in the untreated group. Semen analysis shows that the diabetic group treated with C. gileadensis sap had considerably more sperm count than the untreated group (P < 0.05). CD4⁺, CD8⁺, CD4⁺, CD25⁺, and CD8⁺ CD25⁺ were reduced significantly in diabetic mice treated with C. gileadnesis. In addition, the NOS immunoreactivity is greater in diabetic C. gileadensis treated groups than in the untreated group.

Clinical implications: C. gileadensis induces mice erectile function and fertility.

Strength and limitations: The study does not use laser Doppler flowmetry for the measurement of erectile dysfunction.

Conclusion: C. gileadensis ameliorates infertility and erectile dysfunction in diabetic mice.