Loss of epe1 + extends chronological lifespan in Schizosaccharomyces pombe.

Abstract

Aging is a complex phenomenon that is characterized by the altered regulation of various biological processes over time. One of these, epigenetics, play a crucial role throughout the different stages of eukaryotic life and its alteration is considered a key molecular hallmark of aging. However, the epigenetic factors which are important for lifespan control remain elusive. Here, we used S. pombe as a model organism to study the epigenetic basis of aging. Our study reveals that loss of the epe1 + gene, encoding for the JmjC domain protein Epe1 , extends chronological lifespan and increases H3K9me3 in aged S. pombe cells .