Emergence of Raoultella ornithinolytica as a significant intestinal microbiota in Nigerian Neonates.

African journal of medicine and medical sciences Pub Date : 2023-12-01

B O Ogunbosi, A Kigbu, O O Tongo, A A Adepoju, A E Orimadegun, G N Odaibo, D O Olaleye, O O Akinyinka

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Abstract

Background: There are increasing reports of Raoultella ornithinolytica infection in humans. This study reports significant contribution of Raoultella ornithinolytica to neonatal gut microbiota.

Methods: Rectal swab samples were collected in 70 healthy neonates, within 6-12hours of birth, and days 3, 9, and 14 after birth. Colonization by R. ornithinolytica was evaluated against neonatal characteristics.

Results: Among the 70 neonates, R. ornithinolytica was the fourth most common bacteria isolated. R. ornithinolytica was part of gut microbiota at birth, and on Day 3, Day 9 and Day 14 after birth in 15%, 28.6%, 21.4% and 5.7% of neonates respectively. No factor was associated with R. ornithinolytica colonization, but a trend towards an increased likelihood of colonization among females, asphyxiated and neonates whose mothers had prolonged labour was observed.

Conclusion: R. ornithinolytica has emerged as an important part of gut microbiota among neonates in Nigeria, but its' role in neonatal dysbiosis and infection remains unclear.

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尼日利亚新生儿中出现的溶鸟拉乌尔菌是一个重要的肠道微生物群。

背景：越来越多的报告显示，人类感染了鸟疫腊尔氏菌（Raoultella ornithinolytica）。本研究报告了鸟疫腊尔氏菌对新生儿肠道微生物群的重要贡献：方法：收集了 70 名健康新生儿的直肠拭子样本，分别在出生后 6-12 小时内、出生后第 3 天、第 9 天和第 14 天采集。结果：在 70 名新生儿中，奥尼氏酵母菌对微生物群的影响最大：结果：在 70 名新生儿中，鸟疫杆菌是第四种最常见的分离细菌。出生时、出生后第 3 天、第 9 天和第 14 天，分别有 15%、28.6%、21.4% 和 5.7%的新生儿肠道微生物群中含有鸟疫杆菌。没有任何因素与奥尼氏菌定植有关，但观察到女性、窒息新生儿和母亲分娩时间过长的新生儿定植的可能性有增加的趋势：结论：在尼日利亚的新生儿中，鸟疫杆菌已成为肠道微生物群的重要组成部分，但其在新生儿菌群失调和感染中的作用仍不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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African journal of medicine and medical sciences

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