A Narrative Review of Bioactive Hydrogel Microspheres: Ingredients, Modifications, Fabrications, Biological Functions, and Applications

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Small Pub Date : 2025-03-19 DOI:10.1002/smll.202500426

Haohui Li, Lili Yu, Ze Li, Sicheng Li, Ye Liu, Guiwen Qu, Kang Chen, Luqiao Huang, Zongan Li, Jianan Ren, Xiuwen Wu, Jinjian Huang

{"title":"A Narrative Review of Bioactive Hydrogel Microspheres: Ingredients, Modifications, Fabrications, Biological Functions, and Applications","authors":"Haohui Li, Lili Yu, Ze Li, Sicheng Li, Ye Liu, Guiwen Qu, Kang Chen, Luqiao Huang, Zongan Li, Jianan Ren, Xiuwen Wu, Jinjian Huang","doi":"10.1002/smll.202500426","DOIUrl":null,"url":null,"abstract":"<p>Hydrogel microspheres are important in regenerative medicine and tissue engineering, acting as cargos of cells, drugs, growth factors, bio-inks for 3D printing, and medical devices. The antimicrobial and anti-inflammatory characteristics of hydrogel microspheres are good for treating injured tissues. However, the biological properties of hydrogel microspheres should be modified for optimal treatment of various body parts with different physiological and biochemical environments. In addition, specific preparation methods are required to produce customized hydrogel microspheres with different shapes and sizes for various clinical applications. Herein, the advances in hydrogel microspheres for biomedical applications are reviewed. Synthesis methods for hydrogel precursor solutions, manufacturing methods, and strategies for enhancing the biological functions of these hydrogel microspheres are described. The involvement of bioactive hydrogel microspheres in tissue repair is also discussed. This review anticipates fostering more insights into the design, production, and application of hydrogel microspheres in biomedicine.</p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 25","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/smll.202500426","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Hydrogel microspheres are important in regenerative medicine and tissue engineering, acting as cargos of cells, drugs, growth factors, bio-inks for 3D printing, and medical devices. The antimicrobial and anti-inflammatory characteristics of hydrogel microspheres are good for treating injured tissues. However, the biological properties of hydrogel microspheres should be modified for optimal treatment of various body parts with different physiological and biochemical environments. In addition, specific preparation methods are required to produce customized hydrogel microspheres with different shapes and sizes for various clinical applications. Herein, the advances in hydrogel microspheres for biomedical applications are reviewed. Synthesis methods for hydrogel precursor solutions, manufacturing methods, and strategies for enhancing the biological functions of these hydrogel microspheres are described. The involvement of bioactive hydrogel microspheres in tissue repair is also discussed. This review anticipates fostering more insights into the design, production, and application of hydrogel microspheres in biomedicine.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

生物活性水凝胶微球的综述：成分、修饰、制备、生物学功能和应用

水凝胶微球在再生医学和组织工程中很重要，可以作为细胞、药物、生长因子、3D打印的生物墨水和医疗设备的货物。水凝胶微球具有抗菌和抗炎的特性，有利于损伤组织的治疗。然而，水凝胶微球的生物学特性需要进行修饰，以达到对不同生理生化环境下不同身体部位的最佳治疗。此外，需要特定的制备方法来生产不同形状和大小的定制水凝胶微球，以适应各种临床应用。本文综述了水凝胶微球在生物医学领域的研究进展。描述了水凝胶前体溶液的合成方法、制造方法和增强这些水凝胶微球生物功能的策略。并讨论了生物活性水凝胶微球在组织修复中的作用。本文对水凝胶微球的设计、生产及其在生物医学领域的应用进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.