Dual-responsive Tumbleweed-inspired Soft Robot Based on Poly(N‑isopropylacrylamide) and MoS2 for Targeted Drug Delivery in Stomach

IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Journal of Bionic Engineering Pub Date : 2025-02-07 DOI:10.1007/s42235-025-00650-7
Xiangyu Teng, Shuxuan Yu, Zezheng Qiao, Zhixing Ge, Wenguang Yang
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Abstract

In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N‑isopropylacrylamide) and MoS2. Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS2, the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.

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基于聚(N -异丙基丙烯酰胺)和二硫化钼的双响应风滚草软机器人胃靶向给药
近年来,用于胃内靶向给药的机器人受到了广泛关注。受风滚草的启发,我们设计了一个基于聚(N -异丙基丙烯酰胺)和二硫化钼的双响应软机器人。在可调磁场的作用下,它可以以高达35毫米/秒的频率实现稳定运动,表现出高度的灵活性和可控性。它还可以沿着预定的路径滚动,穿过迷宫,爬过障碍物,以及其他功能。此外,通过利用二硫化钼的光热转换效应,机器人可以使用光打开和关闭,从而控制药物释放。我们设计的软体机器人在胃模型中实现了靶向给药,这标志着一项重大的临床进展,有望彻底改变未来的医学治疗,提高药物治疗的疗效。
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麦克林
MoS2
麦克林
MoS2
阿拉丁
Bis
阿拉丁
NIPAM monomer
来源期刊
Journal of Bionic Engineering
Journal of Bionic Engineering 工程技术-材料科学:生物材料
CiteScore
7.10
自引率
10.00%
发文量
162
审稿时长
10.0 months
期刊介绍: The Journal of Bionic Engineering (JBE) is a peer-reviewed journal that publishes original research papers and reviews that apply the knowledge learned from nature and biological systems to solve concrete engineering problems. The topics that JBE covers include but are not limited to: Mechanisms, kinematical mechanics and control of animal locomotion, development of mobile robots with walking (running and crawling), swimming or flying abilities inspired by animal locomotion. Structures, morphologies, composition and physical properties of natural and biomaterials; fabrication of new materials mimicking the properties and functions of natural and biomaterials. Biomedical materials, artificial organs and tissue engineering for medical applications; rehabilitation equipment and devices. Development of bioinspired computation methods and artificial intelligence for engineering applications.
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