{"title":"Lipid it up: Freed fats drive ferroptosis","authors":"Madison S. Mortensen , Jennifer L. Watts","doi":"10.1016/j.chembiol.2025.02.008","DOIUrl":null,"url":null,"abstract":"<div><div>Polyunsaturated fats promote ferroptosis through their propensity to form toxic lipid peroxides. In this issue of <em>Cell Chemical Biology</em>, Sokol et al.<span><span><sup>1</sup></span></span> report that extracellular lipid depletion leads to increased cell death by ferroptosis. This occurs because fats liberated from triglycerides are modified and incorporated into cellular phospholipids.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 3","pages":"Pages 384-385"},"PeriodicalIF":6.6000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Chemical Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451945625000662","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Polyunsaturated fats promote ferroptosis through their propensity to form toxic lipid peroxides. In this issue of Cell Chemical Biology, Sokol et al.1 report that extracellular lipid depletion leads to increased cell death by ferroptosis. This occurs because fats liberated from triglycerides are modified and incorporated into cellular phospholipids.
Cell Chemical BiologyBiochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
14.70
自引率
2.30%
发文量
143
期刊介绍：
Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
