Disrupting neuron-tumor networking connections

IF 7.2 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Chemical Biology Pub Date : 2025-03-20 DOI:10.1016/j.chembiol.2025.02.006
Cheng-En Shen , Alesandra S. Echeandía Marrero , Yuan Pan
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引用次数: 0

Abstract

Neurons are key to brain tumor pathogenesis. Though direct synaptic connections between neurons and glioblastoma cells had been revealed, the nature of such connections remained enigmatic. In a recent issue of Cell, Tetzlaff et al.1 leveraged monosynaptic retrograde tracing to pinpoint these interactions, demonstrating new therapeutic strategies for targeting malignant neuron-glioma crosstalk.
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破坏神经元与肿瘤的网络连接
神经元是脑肿瘤发病的关键。虽然神经元和胶质母细胞瘤细胞之间的直接突触连接已被揭示,但这种连接的性质仍然是谜。在最近一期的《细胞》杂志上,Tetzlaff等人利用单突触逆行追踪来确定这些相互作用,展示了针对恶性神经元-胶质瘤串扰的新治疗策略。
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来源期刊
Cell Chemical Biology
Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
14.70
自引率
2.30%
发文量
143
期刊介绍: Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.
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