Teng Liu, Zhuoyu Wang, Junjie Li, Weiqiang Li, Rong Liu, Chunyan Zhang, Sirong Gao, Chao Huang
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引用次数: 0
Abstract
A high regio- and chemoselectivity route to the synthesis of 4-quinolone derivatives involving a CsF-catalyzed [2 + 4] tandem annulations under continuous-flow reactor has been developed. This practical and concise protocol between aryne precursors and β-enamino diesters provided a range of structurally diverse 4-quinolones (28 examples) in good to excellent yields. The characteristics of this continuous-flow are safe operation, high regio- and chemoselectivity in a short time. This approach can enrich and develop aryne chemistry, and might provide new opportunities for the discovery of 4-quinolone drugs.
期刊介绍：
The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry:
Liebigs Annalen
Bulletin des Sociétés Chimiques Belges
Bulletin de la Société Chimique de France
Gazzetta Chimica Italiana
Recueil des Travaux Chimiques des Pays-Bas
Anales de Química
Chimika Chronika
Revista Portuguesa de Química
ACH—Models in Chemistry
Polish Journal of Chemistry.
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