{"title":"Nickel-Catalyzed Cyanation of Vinyl Triflates with Isonitrile as a Nucleophilic CN Source","authors":"Yuntong Hu, Jian Qin, Shengqing Zhu, Lingling Chu","doi":"10.1002/adsc.202500200","DOIUrl":null,"url":null,"abstract":"<p>We report a nickel-catalyzed cyanation of vinyl triflates using <i>tert</i>-butyl isonitrile as a nucleophilic CN source. This reaction employs simple Ni(OTf)<sub>2</sub> as the catalyst, operating without exogenous ligands or reductants. The method enables selective and efficient access to a broad range of cyclic and acyclic alkenyl nitriles, accommodating diverse functional groups and substrates, including natural products and pharmaceuticals.</p>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 10","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.202500200","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
We report a nickel-catalyzed cyanation of vinyl triflates using tert-butyl isonitrile as a nucleophilic CN source. This reaction employs simple Ni(OTf)2 as the catalyst, operating without exogenous ligands or reductants. The method enables selective and efficient access to a broad range of cyclic and acyclic alkenyl nitriles, accommodating diverse functional groups and substrates, including natural products and pharmaceuticals.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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