Fabrication And Assessment Of A Ternary Composite Of Cobalt Oxide, Cadmium Sulphide And Carbon Nanotube As A Disposable Sensor For The Sensitive Monitoring Of Tamsulosin In Serum.

Abstract

Tamsulosin is an α1A blocker used to manage lower urinary tract symptoms in prostate hyperplasia patients. Research has shown a marked variation in patients' response to the drug, which may require continuous therapeutic drug monitoring (TDM) to aid in dose manipulations for better treatment outcomes. Electrochemical sensors are the least explored for tamsulosin. Here, we report the first exploration of a facile synthesis and electrochemical study of a ternary nanocomposite of cobalt oxide nanoparticles, cadmium sulfide nanorods, and multiwalled carbon nanotubes (Co3O4@CdS/MWCNT/SPE) and its application for the detection of tamsulosin in serum. A precipitation oxidation and hydrothermal method were used to synthesise Co3O4 nanoparticles and CdS/MWCNT, respectively. Co3O4 and CdS/MWCNT masses were dispersed in deionised water and sonicated to obtain Co3O4@CdS/MWCNT. The fabricated sensor recorded the lowest-ever detection limits of 2.06×10-9 and 3.89×10-9 for CV and SWV. The sensor showed remarkable selectivity in the presence of multiple interfering agents and average recovery was 96.4, with an RSD of 1.38%. This study is the first to report a composite of Co3O4, CdS and MWCNT and the first disposable tamsulosin sensor. As a disposable sensor, the current sensor offers portability and miniaturisation for point-of-care applications.