Decreasing efficiency in deceased donor kidney offer notifications under the new distance-based kidney allocation system

IF 8.2 2区 医学 Q1 SURGERY American Journal of Transplantation Pub Date : 2025-03-17 DOI:10.1016/j.ajt.2025.03.010
Miko Yu , Syed Ali Husain , Joel T. Adler , Lindsey M. Maclay , Kristen L. King , Prateek V. Sahni , David C. Cron , Jesse D. Schold , Sumit Mohan
{"title":"Decreasing efficiency in deceased donor kidney offer notifications under the new distance-based kidney allocation system","authors":"Miko Yu ,&nbsp;Syed Ali Husain ,&nbsp;Joel T. Adler ,&nbsp;Lindsey M. Maclay ,&nbsp;Kristen L. King ,&nbsp;Prateek V. Sahni ,&nbsp;David C. Cron ,&nbsp;Jesse D. Schold ,&nbsp;Sumit Mohan","doi":"10.1016/j.ajt.2025.03.010","DOIUrl":null,"url":null,"abstract":"<div><div>Organ Procurement Organizations (OPOs) recover deceased donor kidneys and place them with matched recipients according to ranked match runs of patients, but offer notification practices differ across the OPOs and have changed following updates to allocation policy (kidney allocation system 250 [KAS250]). This national registry study used batch notification data to quantify time spent on kidney allocation and identify variations in batch notification practices across OPOs before and after the KAS250 allocation system era. Overall allocation time between the first and last offer notifications increased from a median of 1 to 7 hours under the KAS250 allocation system. For match runs of unplaced kidneys, allocation time increased from a median of 18 to 28 hours. Out-of-sequence (OOS) allocation, used by OPOs to limit nonutilization due to excess cold ischemia time, more than doubled in frequency between 2018 and 2022, with median time from first offer to initiation of OOS varying across OPOs from 0 to 47 hours. Increasing rates of organ nonutilization and the observed allocation practice differences based on organ quality demonstrate the urgent need for new approaches to achieve more efficient placement of hard-to-place kidneys. Data-driven approaches to optimize kidney allocation efforts will help ensure fairness in a system that currently allows for wide practice variation and frequent OOS allocation.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 8","pages":"Pages 1696-1706"},"PeriodicalIF":8.2000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Transplantation","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S160061352500139X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

Abstract

Organ Procurement Organizations (OPOs) recover deceased donor kidneys and place them with matched recipients according to ranked match runs of patients, but offer notification practices differ across the OPOs and have changed following updates to allocation policy (kidney allocation system 250 [KAS250]). This national registry study used batch notification data to quantify time spent on kidney allocation and identify variations in batch notification practices across OPOs before and after the KAS250 allocation system era. Overall allocation time between the first and last offer notifications increased from a median of 1 to 7 hours under the KAS250 allocation system. For match runs of unplaced kidneys, allocation time increased from a median of 18 to 28 hours. Out-of-sequence (OOS) allocation, used by OPOs to limit nonutilization due to excess cold ischemia time, more than doubled in frequency between 2018 and 2022, with median time from first offer to initiation of OOS varying across OPOs from 0 to 47 hours. Increasing rates of organ nonutilization and the observed allocation practice differences based on organ quality demonstrate the urgent need for new approaches to achieve more efficient placement of hard-to-place kidneys. Data-driven approaches to optimize kidney allocation efforts will help ensure fairness in a system that currently allows for wide practice variation and frequent OOS allocation.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在新的基于距离的肾脏分配制度下,降低了已故供者肾脏供应通知的效率。
器官采购组织(opo)回收已故供体肾脏,并根据患者的匹配顺序将其与匹配的受者配对,但各器官采购组织提供的通知做法不同,并且随着分配政策的更新而改变(KAS250)。这项国家注册研究使用批通知数据来量化肾脏分配所花费的时间,并确定KAS250前后opo批通知实践的变化。在KAS250下,第一次和最后一次报价通知之间的总体分配时间从中位数1小时增加到7小时。对于未安置肾脏的匹配运行,分配时间从中位数18小时增加到28小时。2018年至2022年期间,OOS分配的频率增加了一倍以上,从首次提供OOS到启动OOS的中位数时间从0小时到47小时不等。OOS分配是opo用来限制因冷缺血时间过长而导致的不使用。不断增加的器官不利用率和观察到的基于器官质量的分配实践差异表明迫切需要新的方法来实现更有效地安置难以放置的肾脏。数据驱动的方法优化肾脏分配工作将有助于确保系统的公平性,目前允许广泛的实践变化和频繁的OOS分配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
18.70
自引率
4.50%
发文量
346
审稿时长
26 days
期刊介绍: The American Journal of Transplantation is a leading journal in the field of transplantation. It serves as a forum for debate and reassessment, an agent of change, and a major platform for promoting understanding, improving results, and advancing science. Published monthly, it provides an essential resource for researchers and clinicians worldwide. The journal publishes original articles, case reports, invited reviews, letters to the editor, critical reviews, news features, consensus documents, and guidelines over 12 issues a year. It covers all major subject areas in transplantation, including thoracic (heart, lung), abdominal (kidney, liver, pancreas, islets), tissue and stem cell transplantation, organ and tissue donation and preservation, tissue injury, repair, inflammation, and aging, histocompatibility, drugs and pharmacology, graft survival, and prevention of graft dysfunction and failure. It also explores ethical and social issues in the field.
期刊最新文献
Immune Gene Correlation Networks Differentiate Both Chronic Lung Allograft Dysfunction and Survival. Feasibility, safety, and effectiveness of prehabilitation programs in patients awaiting liver transplantation: a systematic review and meta-analysis. From Priority to Dead-End: Why are Living Donor Recipients Blocked from Novel Clinical Trials? Dual costimulation blockade with the CD154-specific fusion protein dazodalibep and belatacept for prophylaxis of kidney allograft rejection. Ileal microbial and luminal biomarker dysbiosis precede acute cellular rejection following intestinal transplantation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1