Decreasing Efficiency in Deceased Donor Kidney Offer Notifications Under the New Distance-Based Kidney Allocation System.

IF 8.9 2区 医学 Q1 SURGERY American Journal of Transplantation Pub Date : 2025-03-17 DOI:10.1016/j.ajt.2025.03.010
Miko Yu, Syed Ali Husain, Joel T Adler, Lindsey M Maclay, Kristen L King, Prateek V Sahni, David C Cron, Jesse D Schold, Sumit Mohan
{"title":"Decreasing Efficiency in Deceased Donor Kidney Offer Notifications Under the New Distance-Based Kidney Allocation System.","authors":"Miko Yu, Syed Ali Husain, Joel T Adler, Lindsey M Maclay, Kristen L King, Prateek V Sahni, David C Cron, Jesse D Schold, Sumit Mohan","doi":"10.1016/j.ajt.2025.03.010","DOIUrl":null,"url":null,"abstract":"<p><p>Organ procurement organizations (OPOs) recover deceased donor kidneys and place them with matched recipients according to ranked match runs of patients, but offer notification practices differ across the OPOs and have changed following updates to allocation policy (KAS250). This national registry study used batch notification data to quantify time spent on kidney allocation and identify variation in batch notification practices across OPOs before and after KAS250. Overall allocation time between first and last offer notifications increased from a median of 1 to 7 hours under KAS250. For match runs of unplaced kidneys, allocation time increased from a median of 18 to 28 hours. Out-of-sequence (OOS) allocation, used by OPOs to limit non-utilization due to excess cold ischemia time, more than doubled in frequency between 2018 and 2022, with median time from first offer to initiation of OOS varying across OPOs from 0 to 47 hours. Increasing rates of organ non-utilization and the observed allocation practice differences based on organ quality demonstrate the urgent need for new approaches to achieve more efficient placement of hard-to-place kidneys. Data-driven approaches to optimize kidney allocation efforts will help ensure fairness in a system that currently allows for wide practice variation and frequent OOS allocation.</p>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajt.2025.03.010","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

Abstract

Organ procurement organizations (OPOs) recover deceased donor kidneys and place them with matched recipients according to ranked match runs of patients, but offer notification practices differ across the OPOs and have changed following updates to allocation policy (KAS250). This national registry study used batch notification data to quantify time spent on kidney allocation and identify variation in batch notification practices across OPOs before and after KAS250. Overall allocation time between first and last offer notifications increased from a median of 1 to 7 hours under KAS250. For match runs of unplaced kidneys, allocation time increased from a median of 18 to 28 hours. Out-of-sequence (OOS) allocation, used by OPOs to limit non-utilization due to excess cold ischemia time, more than doubled in frequency between 2018 and 2022, with median time from first offer to initiation of OOS varying across OPOs from 0 to 47 hours. Increasing rates of organ non-utilization and the observed allocation practice differences based on organ quality demonstrate the urgent need for new approaches to achieve more efficient placement of hard-to-place kidneys. Data-driven approaches to optimize kidney allocation efforts will help ensure fairness in a system that currently allows for wide practice variation and frequent OOS allocation.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
18.70
自引率
4.50%
发文量
346
审稿时长
26 days
期刊介绍: The American Journal of Transplantation is a leading journal in the field of transplantation. It serves as a forum for debate and reassessment, an agent of change, and a major platform for promoting understanding, improving results, and advancing science. Published monthly, it provides an essential resource for researchers and clinicians worldwide. The journal publishes original articles, case reports, invited reviews, letters to the editor, critical reviews, news features, consensus documents, and guidelines over 12 issues a year. It covers all major subject areas in transplantation, including thoracic (heart, lung), abdominal (kidney, liver, pancreas, islets), tissue and stem cell transplantation, organ and tissue donation and preservation, tissue injury, repair, inflammation, and aging, histocompatibility, drugs and pharmacology, graft survival, and prevention of graft dysfunction and failure. It also explores ethical and social issues in the field.
期刊最新文献
Corrigendum to 'Establishing targets for goal-directed anesthesia in renal transplantation: A cohort analysis of high-saliency surgical time courses' [American Journal of Transplantation. Volume 24, Issue 11 (2024) Pages 2055-2065]. Decreasing Efficiency in Deceased Donor Kidney Offer Notifications Under the New Distance-Based Kidney Allocation System. Identifying target epitopes paves the way towards peptide-based therapies for tolerance induction. Trained Immunity: Can We Get One Transplanted Kidney to Last a Lifetime? Listing for blood type A2 donors is highly variable and impacts waitlist outcomes among blood type O liver transplantation candidates in the United States.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1