Polymer-Mediated Delivery of Amphotericin B for Fungal Infections.

Abstract

Invasive fungal infections have been an increasingly global issue with high mortality. Amphotericin B (AmB), as the "gold standard" antifungal drug, has broad-spectrum antifungal activity and low clinical resistance. Therefore, AmB is the most commonly used polyene antibiotic for the treatment of invasive fungal infections. However, the serious side effects as well as the low bioavailability of AmB strongly restrict its clinical applications. Polymer, with its diversified molecular design, is widely used in drug delivery in the form of polymeric prodrugs, nanoparticles, hydrogels, etc. Therefore, polymers hold great promise for the delivery of AmB in treating fungal infections. This review summarizes recent advances in polymer-based delivery systems of AmB for the treatment of fungal infections, including polymer-AmB conjugates, nanotechnology-based polymeric delivery systems, hydrogels, and polymeric microneedles. Taking advantage of polymer-based delivery strategies, special attention is paid to reducing the side effects and improving the bioavailability of AmB for safe and effective antifungal therapy. Finally, the limitations and possible future directions of polymer-based AmB delivery systems are discussed.