The Impact of Abnormal Distribution of Abdominal Adiposity and Skeletal Muscle on the Prognosis of Ischemic Stroke.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY Cerebrovascular Diseases Pub Date : 2025-03-19 DOI:10.1159/000545334

Chengcheng Cui, Zhiwen Geng, Haotao Li, Rui Li, Mengxia Lu, Yuqiao Wang, Lulu Xiao, Xinfeng Liu

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引用次数: 0

Abstract

Objective: This study aimed to investigate the role of novel indicators related to obesity in predicting long-term functional outcomes and the risk of stroke recurrence in participants with first-ever acute ischemic stroke (AIS).

Methods: The area and density of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle (SM) at the third lumbar level, as well as the VAT area (VATA)-to-SM area (SMA) ratio (VSR) and the SAT area-to-SMA ratio (SSR), were assessed using whole-abdominal CT upon admission. The primary endpoint was the recurrence of stroke. The secondary outcomes were all-cause mortality and cardio-cerebrovascular origin death (CCVD) specifically due to cardiovascular and cerebrovascular diseases. Cox's proportional hazards regression model was used to examine the associations between the novel indicators of obesity and clinical outcomes.

Results: A total of 1007 participants were enrolled, with an average follow-up time of 1445 days. The participants in the high VSR group had a higher rate of stroke recurrence (adjusted hazard ratio, 2.06 [95% CI, 1.35-3.14]; p = 0.001). According to the adjusted analysis, high VSR was significantly associated with an increased risk of all-cause mortality (hazard ratio, 2.26 [95% CI, 1.58-3.24]; p < 0.001) and CCVD (hazard ratio, 2.49 [95% CI, 1.65-3.78]; p < 0.001).

Conclusions: A higher VSR was associated with a higher risk of mortality and stroke recurrence in participants with first-ever AIS.

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.