Histological and Clinical Characteristics of Oral Squamous Cell Carcinoma Analyzed by Digitally Assembled Whole-Mount Sections

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Oral Pathology & Medicine Pub Date : 2025-03-19 DOI:10.1111/jop.13630

Han Gyeol Kim, Nayeon Choi, Manki Chung, Han-Sin Jeong, Junhun Cho

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Abstract

Background

The diagnosis of oral squamous cell carcinoma (OSqCC) is sometimes delayed. In this study, we attempted to comprehensively analyze the surface and cross section of OSqCC using whole-mount sections.

Methods

Representative cross sections of 41 pT2 and pT3 OSqCC were digitally assembled, and whole-mount sections were reconstructed. In the cross section of the tumor, the degree of differentiation was classified as well/moderately differentiated (WDMD) and poorly differentiated (PD); and the surface of the specimen was divided into four types: benign-looking epithelium, dysplasia, carcinoma, and ulceration.

Results

In the cross-sectional analysis, 17 cases (41.5%) consisted of only WDMD, and the PD component was predominant in seven cases (17.1%). In the remaining 17 patients, the PD component was partial (< 50%). When grouping noncancerous lesions (benign-looking epithelium and dysplasia, BnDy) and cancerous lesions (carcinoma and ulceration, CaUl) in the surface analysis, the proportion of CaUl was significantly lower in the tongue than in other oral sites (p = 0.009) In the survival analysis, although not statistically significant, the overall survival of partial PD patients was more similar to that of the predominant PD group compared to that of the WDMD-only group.

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口腔鳞状细胞癌的组织学和临床特征的数字组装整片切片分析。

背景：口腔鳞状细胞癌（OSqCC）的诊断有时会延迟。在本研究中，我们尝试使用整片切片对OSqCC的表面和横截面进行综合分析。方法：对41例pT2和pT3 OSqCC的代表性横切面进行数字化组装，重建整片切片。在肿瘤横切面上，分化程度分为中度分化（WDMD）和低分化（PD）；标本表面分为四种类型：良性上皮、不典型增生、癌和溃疡。结果：在横断面分析中，17例（41.5%）仅由WDMD组成，7例（17.1%）以PD成分为主。在其余17例患者中，PD成分部分(

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.