Lipid composition of myelin and protein--lipid complex in a neurological rabbit mutant.

Neurochemical pathology Pub Date : 1988-04-01 DOI:10.1007/BF03160139

H Wikel, K Domańska-Janik, J Strosznajder

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引用次数: 1

Abstract

The neurological mutant of the paralytic tremor "pt" rabbit is characterized by a reduced amount of myelin to 25-30% of control with no change in specific activity for 2',3'-cyclic nucleotide phosphodiesterase. The ratio of total lipids to protein was higher in "pt" rabbit myelin than in control by about 20%. Analysis of the lipid composition of "pt" rabbit myelin indicated a significantly lower level of galactolipids (by about 30%) and a higher level of gangliosides compared to control. The percentage composition of phospholipids in "pt" myelin was characterized by a lower proportion of acidic phospholipids (polyphosphoinositides, phosphatidic acid, phosphatidylserine). The protein-lipid complex in "pt" rabbit myelin was decreased by about 10-15% compared to control. The ratio by weight of protein to lipid in myelin was 0.24 and 0.20 in control and "pt" rabbit, respectively, but in protein-lipid complex isolated from myelin it was 1.73 in control and 0.72 in "pt" rabbit. Protein-lipid complex isolated from myelin of "pt" rabbit brain contained about 34% less protein and about 16% less acidic phospholipids but neutral phospholipids were increased by 24%. The lipid abnormalities in "pt" rabbit myelin and in the composition of protein-lipid complex may be responsible for the disturbances of myelin formation and compaction in "pt" rabbit.

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兔神经系统突变体髓磷脂和蛋白脂复合物的脂质组成。

麻痹性震颤“pt”兔的神经系统突变的特点是髓磷脂的量减少到对照的25-30%，而2'，3'-环核苷酸磷酸二酯酶的特异性活性没有变化。“pt”兔髓磷脂组总脂蛋白比对照组高约20%。对“pt”兔髓磷脂脂质组成的分析表明，与对照组相比，半乳脂质水平显著降低(约30%)，神经节苷类含量较高。磷脂在“pt”髓磷脂的百分比组成的特点是酸性磷脂(多磷酸肌醇、磷脂酸、磷脂酰丝氨酸)的比例较低。与对照组相比，“pt”兔髓磷脂中的蛋白脂复合物减少了约10-15%。正常兔和“pt”兔髓磷脂中蛋白质与脂肪的重量比分别为0.24和0.20，而从髓磷脂中分离的蛋白-脂复合物在正常兔和“pt”兔中分别为1.73和0.72。从“pt”兔脑髓磷脂中分离得到的蛋白脂复合物中蛋白质含量减少约34%，酸性磷脂含量减少约16%，而中性磷脂含量增加24%。兔髓磷脂中脂质异常和蛋白脂复合物组成异常可能是兔髓磷脂形成和压实紊乱的原因。

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Neurochemical pathology

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