The application of magnetic susceptibility separation for measuring cerebral oxygenation in preterm neonates.

Abstract

Background: Quantitative susceptibility mapping (QSM), a magnetic resonance imaging (MRI) modality sensitive to deoxyhemoglobin, is a promising method for measuring cerebral oxygenation in human neonates. Paramagnetic sources, like deoxyhemoglobin, however, can be obscured by diamagnetic sources such as water and myelin. This study evaluated whether QSM images, or isolated paramagnetic components, are more accurate for measuring oxygenation of cerebral veins of preterm neonates, and explored oxygenation differences between the major cerebral veins.

Methods: 19 preterm neonates were scanned on at term equivalent age on a 3T MRI using a multi-echo susceptibility-weighted imaging sequence. Susceptibility values were calculated from QSM images to determine oxygen saturation (SvO₂) in the superior sagittal sinus (SSS) and central cerebral veins (CCV). The paramagnetic components of QSM images were isolated, and SvO₂ values were recalculated.

Results: The mean SvO₂ values from QSM were 72.4% (SD, 3.4%) for the SSS and 68.7% (SD, 3.5%) for the CCV. SvO₂ values for paramagnetic components were 58.1% (SD, 7.3%) for the SSS and 57.7% (SD, 7.0%) for the CCV.

Conclusion: While paramagnetic component decomposition yielded SSS values closer to those found in the literature, it increased variability. No significant oxygenation differences were found between the SSS and CCV, contrasting with prior studies.

Impact: This study evaluated the use of QSM and its paramagnetic components to measure cerebral oxygenation in neonates. By comparing susceptibility-derived oxygen saturation (SvO₂) in the superior sagittal sinus (SSS) and central cerebral veins (CCV), it adds to the field of neonatal cerebral oxygenation measurement. Decomposing QSM into paramagnetic components shows potential for improving SvO₂ accuracy, particularly in the SSS, though variability remains a challenge. The results suggest no significant oxygenation difference between the SSS and CCV, contrasting with previous findings, indicating a need for further research on neonatal venous oxygenation.