{"title":"GPX4 methylation puts a brake on ferroptosis","authors":"Graeme I. Lancaster, Andrew J. Murphy","doi":"10.1038/s41556-025-01640-x","DOIUrl":null,"url":null,"abstract":"Ferroptosis is a form of cell death that occurs in many pathological conditions and is a target for cancer therapy. The enzyme GPX4 is the primary means by which cells guard against ferroptosis. A study now demonstrates that methylation of GPX4 promotes its stabilization, and that preventing GPX4 methylation improves cancer therapy.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"27 4","pages":"556-557"},"PeriodicalIF":19.1000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41556-025-01640-x","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ferroptosis is a form of cell death that occurs in many pathological conditions and is a target for cancer therapy. The enzyme GPX4 is the primary means by which cells guard against ferroptosis. A study now demonstrates that methylation of GPX4 promotes its stabilization, and that preventing GPX4 methylation improves cancer therapy.
期刊介绍：
Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to:
-Autophagy
-Cancer biology
-Cell adhesion and migration
-Cell cycle and growth
-Cell death
-Chromatin and epigenetics
-Cytoskeletal dynamics
-Developmental biology
-DNA replication and repair
-Mechanisms of human disease
-Mechanobiology
-Membrane traffic and dynamics
-Metabolism
-Nuclear organization and dynamics
-Organelle biology
-Proteolysis and quality control
-RNA biology
-Signal transduction
-Stem cell biology
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