Front Cover: Manganese-Catalyzed Selective ortho-Deuteration of Aromatic Amidines with D₂O (Eur. J. Org. Chem. 10/2025)

Abstract

The Front Cover illustrates a transformation pathway leading to the deuteration of amidines, catalyzed by Mn(CO)₅Br, with acetyl groups acting as the concerted metallation–deprotonation base. Two production line designs, reflecting varying efficiencies, emphasize that the reaction predominantly proceeds through a manganese-catalyzed five-membered cyclic transition state and highlight the efficacy and regioselectivity of the catalytic process. More information can be found in the Research Article by J.-F. Bai, J. Chen and co-workers (DOI: 10.1002/ejoc.202401374).