Supramolecular Zwitterionic Network Enabling Environment-Tolerant, Transparent, Adhesive, and Biocompatible Organogel for Epidermal Electronics

IF 5.2 Q1 POLYMER SCIENCE ACS Macro Letters Pub Date : 2025-03-20 DOI:10.1021/acsmacrolett.5c00098

Min Gong, Xiaobo Wang, Heng An, You Wu, Liang Zhang, Xiang Lin, Fengxian Gao, Zhen Wu, Dongrui Wang

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Abstract

Ionic hydrogels are ideal for soft bioelectronics due to their softness, stretchability, and ion-mediated signal transduction. However, traditional hydrogels face dehydration and freezing issues. Inspired by natural skin, this study creates a supramolecular ionic organogel using silk fibroin, zwitterionic polymers, Ca²⁺, and ethylene glycol (EG). The organogel is conductive, highly stretchable, adhesive, environmentally stable, and biocompatible. Theoretical calculations reveal that interactions among Ca²⁺, zwitterionic groups, EG, and water are stronger than water–water interactions, converting “free” water into “locked” water. This mechanism allows the organogel to retain over 90% of its weight after 30 days at 25 °C and 60% relative humidity, while also resisting freezing by disrupting ice formation. Its conductivity, adhesion, and biocompatibility enable applications in on-skin strain sensors and electrodes for monitoring motion and recording electrophysiological signals. This work elucidates molecular interactions in organogel networks, provides a design framework for environmentally tolerant organogel, and advances ion-conductive bioelectronics.

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超分子两性离子网络使环境耐受、透明、粘接和生物相容性有机凝胶用于表皮电子学

离子水凝胶由于其柔软性、可拉伸性和离子介导的信号转导，是软生物电子学的理想选择。然而，传统的水凝胶面临脱水和冷冻的问题。受天然皮肤的启发，这项研究利用丝素蛋白、两性离子聚合物、Ca2+和乙二醇（EG）创造了一种超分子离子有机凝胶。有机凝胶具有导电性、高度可拉伸性、粘接性、环境稳定性和生物相容性。理论计算表明，Ca2+、两性离子基团、EG和水之间的相互作用比水-水相互作用更强，将“自由”水转化为“锁定”水。这种机制使有机凝胶在25°C和60%相对湿度下30天后保持90%以上的重量，同时还可以通过破坏冰的形成来抵抗冻结。它的导电性、粘附性和生物相容性使其能够应用于皮肤上的应变传感器和电极，用于监测运动和记录电生理信号。这项工作阐明了有机凝胶网络中的分子相互作用，为环境耐受的有机凝胶提供了设计框架，并推进了离子导电生物电子学。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.

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