Core-Shell Structure-Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Functional Materials Pub Date : 2025-03-21 DOI:10.1002/adfm.202500329

Shuangying Li, Ren Li, Xiuwen Zhang, Yueyuan Zhu, Dong Wang, Wenpeng Cui, Hechen Chai, Yushun Hou, Shaoxiang Li

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Abstract

Herein, MIL-88b-NH₂ nanocage is designed with adenine inside the cage and tannins as gating outside the cage. Based on this core-shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously and exogenously at different stages of wound healing. The engineered hydrogel is designed to have tunable adhesion and intelligence. The optimal PCMAT-0.3 hydrogel reduced the pore size to ≈13.5 µm under endogenous response conditions, and the antimicrobial performance reached more than 80% within 6 h. Tensile strength and strain at break are reduced by 8.47% and 60.52% respectively under exogenous response conditions. Evaluation of the healing effect on mouse back wound tissue shows that the wound healing rate is significantly better than the control group without nanocage incorporation on day 14. It provides an idea for the development of smart response hydrogel wound dressing that integrates multifunctionality.

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.