Core-Shell Structure-Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing

IF 19 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Functional Materials Pub Date : 2025-03-21 DOI:10.1002/adfm.202500329

Shuangying Li, Ren Li, Xiuwen Zhang, Yueyuan Zhu, Dong Wang, Wenpeng Cui, Hechen Chai, Yushun Hou, Shaoxiang Li

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Abstract

Herein, MIL-88b-NH₂ nanocage is designed with adenine inside the cage and tannins as gating outside the cage. Based on this core-shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously and exogenously at different stages of wound healing. The engineered hydrogel is designed to have tunable adhesion and intelligence. The optimal PCMAT-0.3 hydrogel reduced the pore size to ≈13.5 µm under endogenous response conditions, and the antimicrobial performance reached more than 80% within 6 h. Tensile strength and strain at break are reduced by 8.47% and 60.52% respectively under exogenous response conditions. Evaluation of the healing effect on mouse back wound tissue shows that the wound healing rate is significantly better than the control group without nanocage incorporation on day 14. It provides an idea for the development of smart response hydrogel wound dressing that integrates multifunctionality.

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基于核壳结构的智能水凝胶伤口敷料，内源性和外源性双粘附动态响应促进伤口愈合

本文设计了MIL-88b-NH2纳米笼，笼内采用腺嘌呤，笼外采用单宁作为门控。基于这种核壳结构，聚乙烯醇/羧甲基壳聚糖/MIL/腺嘌呤/单宁酸（PCMAT）水凝胶能够在不同的伤口愈合阶段产生内源性和外源性反应。工程水凝胶被设计成具有可调的附着力和智能。最优的PCMAT-0.3水凝胶在内源响应条件下孔径减小至≈13.5µm，抗菌性能在6 h内达到80%以上，抗拉强度和断裂应变在外源响应条件下分别降低8.47%和60.52%。对小鼠背部伤口组织愈合效果的评价显示，第14天伤口愈合率明显优于未掺入纳米笼的对照组。为开发集多种功能于一体的智能反应水凝胶伤口敷料提供了思路。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.