Changdong Shao, Jingyi Liu, Yanan Shen, Li Li, Chen Ma, Zhengsong Hu, Yuhe Kan, Ping Chen and Tingting Zhang
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引用次数: 0
Abstract
An efficient and convenient method for oxidative mono- and di-bromination of 8-aminoquinoline amides is presented, utilizing hydrogen bromide (HBr) as the brominating reagent and dimethyl sulfoxide (DMSO) as a mild oxidant. Copper salts act as Lewis acid catalysts, facilitating the bromination process. The formation of C5-monobrominated products is promoted by copper sulfate (CuSO4·5H2O), whereas the generation of C5, C7-dibrominated products necessitates the participation of copper nitrate (Cu(NO3)2·3H2O). A wide range of substrates bearing diverse functional groups undergo smooth transformation, resulting in brominated products with good to excellent yields.
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An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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