Health care-associated infections and antimicrobial use: The third point prevalence survey on 42 acute care hospitals in Piedmont, Italy, 2022

IF 2.4 3区医学 Q2 INFECTIOUS DISEASES American journal of infection control Pub Date : 2025-03-18 DOI:10.1016/j.ajic.2025.03.019

Antonino Russotto MD , Claudia Gastaldo MD , Stefania Di Giacomo MD , Stefano Bazzolo PhD , Dario Gamba MD , Carla Maria Zotti PhD , Costanza Vicentini MD , on behalf of the “UPRI” working group

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Abstract

Background

Health care-associated infections (HAIs), antibiotic use (AMU), and antimicrobial resistance (AMR) are critical indicators of health care quality and antimicrobial stewardship. Point prevalence surveys provide essential data for optimizing infection prevention and control strategies. We aimed to describe the prevalence of HAIs, AMU, and AMR in Piedmont, Italy, highlighting associations with hospital complexity and patient characteristics.

Methods

Data included hospital characteristics, demographics, HAI, AMU, AMR, and clinical characteristics. Prevalence ratios were calculated to compare rates across subgroups.

Results

The prevalence of HAIs was 8%. AMU prevalence decreased to 40% from 42.8% in 2016. Trends in AMU aligned with the “Italian National Action Plan to contrast AMR” (PNCAR) goals, showing reduced fluoroquinolone use and increased amoxicillin prescriptions. AMR trends showed improvements in oxacillin-resistant Staphylococcus aureus and cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae.

Conclusions

The results highlight the critical importance of sustained investment in infection prevention and control measures and robust antimicrobial stewardship programs.

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医疗保健相关感染和抗菌药物使用：2022年意大利皮埃蒙特42家急症护理医院的第三点患病率调查

背景：医疗相关感染（HAIs）、抗生素使用（AMU）和抗菌药物耐药性（AMR）是衡量医疗质量和抗菌药物管理水平的重要指标。点流行率调查为优化感染预防和控制（IPC）策略提供了重要数据：目的：描述意大利皮埃蒙特各级医院和病房的 HAIs、AMU 和 AMR 的流行情况，强调与医院复杂性和患者护理特点的关联：数据包括医院特征、人口统计学、HAI、AMU、AMR 和临床特征。计算患病率比（PRs）以比较不同亚组的患病率：结果：HAI 的发生率为 8%，侵入性器械使用率增加是其中一个原因（PR 1.71，95% CI 1.64-1.78）。AMU发病率从2016年的42.8%降至40%。抗生素的使用趋势与 "意大利国家反AMR行动计划"（PNCAR）的目标一致，显示氟喹诺酮类药物的使用减少，阿莫西林处方增加。AMR趋势显示，耐沙西林金黄色葡萄球菌、耐头孢菌素大肠埃希菌和肺炎克雷伯菌的情况有所改善：研究结果突出表明，持续投资于 IPC 措施和强有力的抗菌药物管理计划至关重要。解决这些关键领域的问题对于减轻人感染性疾病的负担、促进抗生素的合理使用以及最终改善整个地区的患者护理和治疗效果至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)