Neuroscience in pictures: Functional neurological disorder

Abstract

Functional neurological disorder (FND) is a biopsychosocially-complex, prevalent, and potentially disabling neuropsychiatric condition. In this pictorial review, we explore the complexity of FND, from its diagnosis and conceptualization to current mechanistic understandings. We highlight advances in neuroimaging research that have revealed structural and functional brain alterations in FND and discuss a variety of factors that may serve as predisposing vulnerabilities for the development of this condition and/or perpetuate symptoms. This overview is designed as an initial teaching resource to educate trainees, clinicians, and researchers, highlighting core concepts in the literature on FND. Given that mechanistic research in FND is at a relatively early stage and is rapidly evolving, the interested reader should aim to continue updating their mechanistic understanding of FND as research further advances in this area.