Yuting Wu, Yuxin Liu, Ziman Jiao, Xin Chen, Haiyu Li, Yunhao Zhou, Guanghui Liu
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引用次数: 0
Abstract
Objective: The association between the weight-adjusted waist index (WWI) and age-related macular degeneration (AMD) in US adults aged 40 years and older is unknown. The goal of this study was to ascertain a possible association between the two.
Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) in the US from 2005 to 2008. The WWI was calculated by dividing waist circumference (WC) by the square root of body weight (kg). AMD was diagnosed based on distinctive features observed in the fundus, using a standard classification system. Weighted logistic regression analyses were conducted to investigate the association between the WWI and AMD. Spline smoothing and threshold effects were applied to explore non-linear correlations. Subgroup analyses were performed to identify underlying covariates affecting this relationship. In addition, receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive power of the WWI for AMD.
Results: A total of 5,132 participants were enrolled in this study. The results showed a significant positive association between the WWI and risk of AMD (OR = 1.76 (1.52, 2.04); p < 0.0001). When the WWI was categorized into tertiles, the highest group exhibited a stronger association compared to the lowest tertile (OR = 2.90 (2.18, 3.86); p < 0.0001) in model 1. The subgroup analyses and interaction tests indicated that the relationship between the WWI and AMD was stable across various populations. The spline smoothing and threshold effects showed a positive non-linear correlation between the WWI and AMD incidence. Furthermore, compared to body mass index (BMI), WC, and weight, the WWI showed better predictability for AMD, as shown by the ROC analysis.
Conclusion: There exists a positive non-linear association between the WWI and AMD in US adults aged 40 years and older. The WWI-related obesity management is necessary for the prevention and treatment of AMD.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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