{"title":"Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study.","authors":"Hongming Yin, Yongjin Wang, Yujia Chen, Qayyum Shehzad, Feng Xiao","doi":"10.1186/s12944-025-02531-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>& aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists' attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.</p><p><strong>Methods: </strong>The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.</p><p><strong>Results: </strong>Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [OR<sub>T3-T1</sub> = 0.22 (0.12-0.41), OR<sub>T3-T1</sub> = 0.29 (0.15-0.54), OR<sub>T3-T1</sub> = 0.49 (0.27-0.88), and OR<sub>T3-T1</sub> = 0.19 (0.09-0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [OR<sub>T1-T3</sub> = 2.02 (1.11-3.70), OR<sub>T1-T3</sub> = 2.10 (1.15-3.87), OR<sub>T1-T3</sub> = 2.82 (1.53-5.30), and OR<sub>T1-T3</sub> = 2.07 (1.12-3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.</p><p><strong>Conclusion: </strong>The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"101"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02531-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: & aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists' attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.
Methods: The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.
Results: Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [ORT3-T1 = 0.22 (0.12-0.41), ORT3-T1 = 0.29 (0.15-0.54), ORT3-T1 = 0.49 (0.27-0.88), and ORT3-T1 = 0.19 (0.09-0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [ORT1-T3 = 2.02 (1.11-3.70), ORT1-T3 = 2.10 (1.15-3.87), ORT1-T3 = 2.82 (1.53-5.30), and ORT1-T3 = 2.07 (1.12-3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.
Conclusion: The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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