[Association between remnant cholesterol and cardio-cerebrovascular mortality in the elderly in communities of Beijing].

Abstract

Objective: To analyze the association between different lipid indicators and cardio-cerebrovascular mortality in the elderly, identify a better lipid indicator for the risk for cardio-cerebrovascular mortality in the elderly in communities of Beijing. Methods: The elderly aged 60 years and above were selected from the Beijing Healthy Aging Cohort Study from July 2009 to September 2015. Remnant cholesterol (RC) was derived by calculation. The Cox proportional hazard regression models determined the HR and 95%CI incidating the associations of baseline different lipid indicators with cardio-cerebrovascular and all-cause mortality. Results: By March 31, 2021, with a mean follow-up duration of 6.88 years in the study population, a total of 492 cardio-cerebrovascular deaths and 1 056 all-cause deaths wre recorded. The HR values indicating the association between LDL-C, HDL-C, and RC were 0.87 (95%CI: 0.78-0.97), 0.46 (95%CI: 0.35-0.62), and 1.29 (95%CI: 1.14-1.45) for cardio-cerebrovascular mortality, respectively, and 0.93 (95%CI: 0.86-1.00), 0.66 (95%CI: 0.55-0.80) and 1.22 (95%CI: 1.12-1.33) for all-cause mortality. The associations of RC and HDL-C with cardio-cerebrovascular mortality were consistent regardless of hyperlipidemia in the elderly. Subgroup analyses showed that elevated RC was associated with increased risk for cardio-cerebrovascular mortality, and elevated HDL-C was associated with decreased risk for cardio-cerebrovascular mortality in the elderly in different gender, age, smoking status, drinking status, and diabetes status groups in communities of Beijing. Conclusion: RC might be a better potential lipid indicator for the risk for cardio-cerebrovascular mortality in the elderly in communities compared with traditional cholesterol indicator.