Recent trends in polycystic ovary syndrome treatment based on adult stem cell therapies.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2025-09-01 Epub Date: 2025-03-21 DOI:10.5653/cerm.2024.07248
Hyeri Park, Ji Woong Han, Gi Jin Kim
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Abstract

Adult stem cell therapy has emerged as a prominent area of interest in regenerative medicine, drawing attention from numerous researchers who are investigating its potential for treating degenerative diseases, especially those affecting the reproductive system. Despite the growing focus, critical elements such as the optimization of treatment parameters (e.g., transplantation [Tx] route, cell dosage) and enhancement of therapeutic efficacy are still areas of uncertainty. This review paper presents a thorough analysis of recent preclinical and clinical studies on adult stem cell therapy for ovarian dysfunction, specifically targeting conditions like polycystic ovary syndrome (PCOS). By examining these studies, the review seeks to clarify the current state of knowledge and pinpoint gaps in understanding, thereby establishing a robust foundation for future advancements in adult stem cell therapies aimed at ovarian dysfunction. Ultimately, this paper aims to offer valuable insights that could lead to improved treatment strategies in the field of reproductive system diseases.

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基于成体干细胞疗法的多囊卵巢综合症治疗的最新趋势。
成体干细胞治疗已经成为再生医学的一个重要领域,吸引了许多研究人员的注意,他们正在研究其治疗退行性疾病的潜力,特别是那些影响生殖系统的疾病。尽管越来越受到关注,但关键因素,如治疗参数的优化(如移植[Tx]途径,细胞剂量)和治疗效果的增强仍然是不确定的领域。本文综述了近年来成人干细胞治疗卵巢功能障碍的临床前和临床研究,特别是针对多囊卵巢综合征(PCOS)等疾病。通过检查这些研究,本综述旨在澄清目前的知识状况,并指出理解上的差距,从而为未来针对卵巢功能障碍的成体干细胞治疗的进展奠定坚实的基础。最终,本文旨在提供有价值的见解,可以导致在生殖系统疾病领域改善治疗策略。
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