Association between exposure to perfluoroalkyl substances (PFASs) and risk of hyperemesis gravidarum

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Pollution Pub Date : 2025-03-21 DOI:10.1016/j.envpol.2025.126103

Lan Zhang , Xiuxiu Ma , Tong Su , Yue Wang , Miaomiao Hai , Feifei Qi , Le Ma , Shunming Zhang , Jing Lin

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Abstract

The fluctuation of endocrine hormones during early pregnancy plays an important role in the pathogenesis of hyperemesis gravidarum (HG). As an endocrine disrupting chemical (EDC), perfluoroalkyl substances (PFASs) exert an impact on pregnancy-related complications by altering hormone balances throughout gestation. Despite this potential impact, the relationship between serum PFAS levels in early pregnancy and the risk of HG has not been previously investigated. A total of 98 HG cases and 495 controls were included in this study from the Xi'an Birth Cohort Study. In total, serum levels of 10 PFASs were measured using High Performance Liquid Chromatography with tandem Mass Spectrometry (HPLC-MS/MS) during early pregnancy. Binary logistic models were applied to evaluate the associations between individual PFAS levels and HG. Weighted quantile sum (WQS) regression models and Bayesian kernel machine regression (BKMR) models were performed to test the overall effect of the PFAS mixture on HG. After adjusting for confounding variables, the highest tertile concentrations of perfluoroundecanoic acid (PFUnDA) (OR: 3.49, 95 %CI: 1.31–9.29), and perfluorododecanoic acid (PFDoA) (OR: 3.13, 95 % CI: 1.40–6.98) were significantly associated with a higher risk of HG, while highest tertile of perfluorohexanoic acid (PFHxA) (OR: 0.34; 95 % CI: 0.16–0.73), and PFOS (OR: 0.35; 95 % CI: 0.13–0.97) were inversely associated with HG. The WQS index showed a positive correlation with HG risk (β = 0.80; 95 % CI: 0.02, 1.57), with notable contributions from PFDoA (0.952), PFUnDA (0.159), and perfluorobutanoic acid (PFBA) (0.146). In addition, the joint effect of the PFAS mixture was positively associated with HG, with PFDoA (posterior inclusion probability (PIP) = 0.78) and PFUnDA (PIP = 0.75) being identified as the primary contributors. Our findings indicate that exposure to PFAS mixture during early pregnancy was associated with an increased risk of HG, with PFDoA and PFUnDA being the major contributors.

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接触全氟烷基物质（PFASs）与妊娠剧吐风险之间的关系

妊娠早期内分泌激素的波动在妊娠剧吐（hyperemesis gravidarum， HG）的发病机制中起重要作用。作为一种内分泌干扰物质，全氟烷基物质（PFASs）通过改变整个妊娠期的激素平衡，对妊娠相关并发症产生影响。尽管存在这种潜在影响，但妊娠早期血清PFAS水平与HG风险之间的关系尚未被研究过。来自西安出生队列研究的98例HG病例和495例对照纳入本研究。采用高效液相色谱串联质谱法（HPLC-MS/MS）测定妊娠早期血清中10种PFASs的含量。采用二元logistic模型评估个体PFAS水平与HG之间的关系，采用加权分位数和（WQS）回归模型和贝叶斯核机回归（BKMR）模型检验PFAS混合物对HG的总体影响。在调整混杂变量后，全氟十烷酸（PFUnDA）（OR: 3.49, 95%CI: 1.31-9.29）和全氟十二烷酸（PFDoA） (OR: 3.13, 95%CI：1.40-6.98)与HG的高风险显著相关，而全氟己酸（PFHxA）的最高百分比(OR: 0.34；95% CI: 0.16-0.73)和全氟辛烷磺酸(OR: 0.35；95% CI: 0.13-0.97)与HG呈负相关，WQS指数与HG风险呈正相关(β= 0.80；95% CI: 0.02, 1.57), PFDoA (0.952), PFUnDA（0.159）和全氟丁酸（PFBA）（0.146）的贡献显著。此外，PFAS混合物的联合效应与HG呈正相关，其中PFDoA（后验包合概率(PIP)=0.78）和PFUnDA （PIP=0.75）被确定为主要影响因素。我们的研究结果表明，妊娠早期暴露于PFAS混合物与HG风险增加有关，其中PFDoA和PFUnDA是主要因素。

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.