Pub Date : 2025-03-21DOI: 10.1016/j.envpol.2025.126102
Bailey Tator, Mitchell Le Sage, Rick A. Relyea
Freshwater salinization is occurring around the world and impacting a wide variety of freshwater species that have evolved under low-salt conditions. Salt pollution reduces the survival of many freshwater taxa, but we know less about the effects of salt on individual traits. Moreover, we know even less about how salt pollution may affect phenotypically plastic traits that have evolved in response to natural stressors. In this study, we examined wood frog tadpoles (Rana sylvatica), which are a model system for predator-induced plasticity, and determined how their growth, behavior, and morphology changed in the presence of chemical cues from dragonflies (Anax junius) under four concentrations of NaCl (16, 250, 500, and 1,000 mg Cl-/L). Early in the experiment, the tadpoles reduced their feeding activity in response to predator cues but did not respond to increasing salt concentrations. Tadpole mass increased with predator cues but decreased with increased salt concentrations. As expected, the predator cues induced relatively deeper tails and tail muscles, while inducing relatively shorter bodies and narrower mouths. However, we also discovered that salt induced relatively longer tails, longer bodies, and smaller eyes. Interestingly, the predator effects did not interact with salt effects for any of the traits. These results suggest that freshwater salinization has the potential to alter the traits of other freshwater species, but the effects may simply be additive. Future studies should examine salt-induced changes in a diversity of other freshwater species and investigate whether salt-induced changes in morphology have consequences to individual performance.
{"title":"Additive effects of freshwater salinization on the predator-induced traits of larval amphibians","authors":"Bailey Tator, Mitchell Le Sage, Rick A. Relyea","doi":"10.1016/j.envpol.2025.126102","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126102","url":null,"abstract":"Freshwater salinization is occurring around the world and impacting a wide variety of freshwater species that have evolved under low-salt conditions. Salt pollution reduces the survival of many freshwater taxa, but we know less about the effects of salt on individual traits. Moreover, we know even less about how salt pollution may affect phenotypically plastic traits that have evolved in response to natural stressors. In this study, we examined wood frog tadpoles (<em>Rana sylvatica</em>), which are a model system for predator-induced plasticity, and determined how their growth, behavior, and morphology changed in the presence of chemical cues from dragonflies (<em>Anax junius</em>) under four concentrations of NaCl (16, 250, 500, and 1,000 mg Cl<sup>-</sup>/L). Early in the experiment, the tadpoles reduced their feeding activity in response to predator cues but did not respond to increasing salt concentrations. Tadpole mass increased with predator cues but decreased with increased salt concentrations. As expected, the predator cues induced relatively deeper tails and tail muscles, while inducing relatively shorter bodies and narrower mouths. However, we also discovered that salt induced relatively longer tails, longer bodies, and smaller eyes. Interestingly, the predator effects did not interact with salt effects for any of the traits. These results suggest that freshwater salinization has the potential to alter the traits of other freshwater species, but the effects may simply be additive. Future studies should examine salt-induced changes in a diversity of other freshwater species and investigate whether salt-induced changes in morphology have consequences to individual performance.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"2 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.envpol.2025.126106
Heidel Moronta-Sabad, David Elustondo, Carlos De la Calle, Rocío Santos, Jesús Miguel Santamaría, Juan José Pons, Arturo H. Ariño
Urban population growth has led to an increase in the number of people living near major roads and highways, increasing exposure to roadside air pollution. This has raised significant public health concerns and driven efforts to regulate air quality in these micro-environments. Solutions such as the implementation of vegetation barriers can reduce exposure to traffic-related emissions by influencing pollutant dispersion patterns. Three primary methods are commonly used to characterize pollutant distribution in complex urban environments: (i) geostatistical analysis using remote sensing, (ii) high-precision measurements across physical barriers, and (iii) dispersion models, particularly computational fluid dynamics (CFD) models. Although numerous studies have investigated the role of vegetation in mitigating traffic-related air pollution, most have relied on small-scale assessments or modeled data. This study presents a comprehensive workflow for evaluating the effectiveness of vegetation barriers in improving urban air quality. It utilizes real-world data collected over two years (May 2015-December 2017) using low-cost mobile sensors in Pamplona, Spain –a medium-sized European city representative of 80% of urban areas in Europe– within the framework of the LIFE+Respira project. Seven pollutants (CO, NO, NO2, O3, PM1, PM2.5, and PM10) were analyzed. Results revealed significant reductions in CO, NO, and NO2 levels behind vegetation barriers, while O3 increased. Findings for PMx were mixed, suggesting that barrier effectiveness depends on particle size and vegetation characteristics. These results are consistent with previous research validating the methodology. Future studies could refine this approach, assess long-term vegetation impacts, and explore additional environmental factors influencing urban air pollution dynamics.
{"title":"Evaluating the impact of roadside vegetation barriers on urban air pollution using low-cost mobile sensors","authors":"Heidel Moronta-Sabad, David Elustondo, Carlos De la Calle, Rocío Santos, Jesús Miguel Santamaría, Juan José Pons, Arturo H. Ariño","doi":"10.1016/j.envpol.2025.126106","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126106","url":null,"abstract":"Urban population growth has led to an increase in the number of people living near major roads and highways, increasing exposure to roadside air pollution. This has raised significant public health concerns and driven efforts to regulate air quality in these micro-environments. Solutions such as the implementation of vegetation barriers can reduce exposure to traffic-related emissions by influencing pollutant dispersion patterns. Three primary methods are commonly used to characterize pollutant distribution in complex urban environments: (i) geostatistical analysis using remote sensing, (ii) high-precision measurements across physical barriers, and (iii) dispersion models, particularly computational fluid dynamics (CFD) models. Although numerous studies have investigated the role of vegetation in mitigating traffic-related air pollution, most have relied on small-scale assessments or modeled data. This study presents a comprehensive workflow for evaluating the effectiveness of vegetation barriers in improving urban air quality. It utilizes real-world data collected over two years (May 2015-December 2017) using low-cost mobile sensors in Pamplona, Spain –a medium-sized European city representative of 80% of urban areas in Europe– within the framework of the LIFE+Respira project. Seven pollutants (CO, NO, NO<sub>2</sub>, O<sub>3</sub>, PM<sub>1</sub>, PM<sub>2.5</sub>, and PM<sub>10</sub>) were analyzed. Results revealed significant reductions in CO, NO, and NO<sub>2</sub> levels behind vegetation barriers, while O<sub>3</sub> increased. Findings for PMx were mixed, suggesting that barrier effectiveness depends on particle size and vegetation characteristics. These results are consistent with previous research validating the methodology. Future studies could refine this approach, assess long-term vegetation impacts, and explore additional environmental factors influencing urban air pollution dynamics.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"41 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.envpol.2025.126104
Jannike Falk-Andersson, Rachel Hurley, Amy L. Lusher
Environmental monitoring data to document levels and sources of macrolitter is important for decision makers to prevent and reduce amounts of this pollution. Here we suggest a structured process in developing national monitoring programs. Given limited resources for monitoring, we highlight the importance of including decision makers in prioritizing monitoring needs. The process involves 1) mapping international obligations and national needs, 2) evaluation of whether these are met by available monitoring data and, 3) assessment of nationally implemented and internationally recommended monitoring methods. Application of this approach when providing advice on a Norwegian monitoring program found that data needs are extensive: amounts, composition and sources of litter should be monitored across environmental compartments to understand entry points, transportation routes and litter loads. Monitoring of items targeted in the EU Single-Use Plastics (SUP) Directive is also needed. Data requirements in Norway are partly met in marine compartments through ongoing monitoring, but data collection is insufficient in time and space. Harmonized monitoring protocols are available, but knowledge on designing representative sampling strategies is lacking. Current monitoring does not meet needs for implementing the SUP Directive, nor to document impacts on biota and litter in non-marine compartments. To meet all needs and obligations, monitoring must be strengthened and extended to all environmental compartments using harmonised protocols with high technical readiness. Improved availability and use of data will allow feedback and secure policy relevance. To facilitate appropriate scientific advice when establishing national monitoring programs decision makers should be engaged in prioritization of monitoring needs.
{"title":"Including decision makers in development of cost-efficient litter monitoring - a three step process","authors":"Jannike Falk-Andersson, Rachel Hurley, Amy L. Lusher","doi":"10.1016/j.envpol.2025.126104","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126104","url":null,"abstract":"Environmental monitoring data to document levels and sources of macrolitter is important for decision makers to prevent and reduce amounts of this pollution. Here we suggest a structured process in developing national monitoring programs. Given limited resources for monitoring, we highlight the importance of including decision makers in prioritizing monitoring needs. The process involves 1) mapping international obligations and national needs, 2) evaluation of whether these are met by available monitoring data and, 3) assessment of nationally implemented and internationally recommended monitoring methods. Application of this approach when providing advice on a Norwegian monitoring program found that data needs are extensive: amounts, composition and sources of litter should be monitored across environmental compartments to understand entry points, transportation routes and litter loads. Monitoring of items targeted in the EU Single-Use Plastics (SUP) Directive is also needed. Data requirements in Norway are partly met in marine compartments through ongoing monitoring, but data collection is insufficient in time and space. Harmonized monitoring protocols are available, but knowledge on designing representative sampling strategies is lacking. Current monitoring does not meet needs for implementing the SUP Directive, nor to document impacts on biota and litter in non-marine compartments. To meet all needs and obligations, monitoring must be strengthened and extended to all environmental compartments using harmonised protocols with high technical readiness. Improved availability and use of data will allow feedback and secure policy relevance. To facilitate appropriate scientific advice when establishing national monitoring programs decision makers should be engaged in prioritization of monitoring needs.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"21 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.envpol.2025.126075
Jun He, Li Zhang, Hong Jin, Daoyuan Yang, Li Jia, Bin Han, Haixia Sui, Jiabin Guo
Bisphenol A (BPA) has emerged as a typical contaminant which can induce various adverse effects on human health and environment. BPA exposure and the corresponding human responses can vary across different regions and populations. China is one of the largest producers and consumers of BPA, but the exposure profile of BPA in Chinese population is poorly understood. Physiologically-based pharmacokinetic (PBPK) models are emerging as useful tools to predict the internal exposure profiles of chemicals. Herein, the present study was aimed to predict the exposure profile of BPA in Chinese population by PBPK modeling using external BPA exposure data. A PBPK model specific for oral BPA exposure in Chinese population was established using interspecies and route-to-route extrapolations using pharmacokinetic data from intravenous BPA exposure studies in monkeys. This model was refined and validated using the data concerning BPA physicochemical properties and pharmacokinetic (absorption, distribution, metabolism, and excretion) data from existing literature. Afterward, this model was applied to simulate the internal exposure profile of BPA in Chinese population by integrating external exposure data from the Fifth China Total Diet Survey with physiological parameters specific to Chinese population. Parameter sensitivity and modeling uncertainty were analyzed. Based on the simulated BPA internal profile, human equivalent dose factors (HEDF) were calculated. Our results provide an important basis for assessment of the potential risk of BPA exposure in Chinese population and an essential reference for determination of the safe margin limits for BPA in China.
{"title":"Prediction of the exposure profile of bisphenol A in Chinese population by physiologically-based pharmacokinetics modeling","authors":"Jun He, Li Zhang, Hong Jin, Daoyuan Yang, Li Jia, Bin Han, Haixia Sui, Jiabin Guo","doi":"10.1016/j.envpol.2025.126075","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126075","url":null,"abstract":"Bisphenol A (BPA) has emerged as a typical contaminant which can induce various adverse effects on human health and environment. BPA exposure and the corresponding human responses can vary across different regions and populations. China is one of the largest producers and consumers of BPA, but the exposure profile of BPA in Chinese population is poorly understood. Physiologically-based pharmacokinetic (PBPK) models are emerging as useful tools to predict the internal exposure profiles of chemicals. Herein, the present study was aimed to predict the exposure profile of BPA in Chinese population by PBPK modeling using external BPA exposure data. A PBPK model specific for oral BPA exposure in Chinese population was established using interspecies and route-to-route extrapolations using pharmacokinetic data from intravenous BPA exposure studies in monkeys. This model was refined and validated using the data concerning BPA physicochemical properties and pharmacokinetic (absorption, distribution, metabolism, and excretion) data from existing literature. Afterward, this model was applied to simulate the internal exposure profile of BPA in Chinese population by integrating external exposure data from the Fifth China Total Diet Survey with physiological parameters specific to Chinese population. Parameter sensitivity and modeling uncertainty were analyzed. Based on the simulated BPA internal profile, human equivalent dose factors (HEDF) were calculated. Our results provide an important basis for assessment of the potential risk of BPA exposure in Chinese population and an essential reference for determination of the safe margin limits for BPA in China.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"37 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.envpol.2025.126092
Max Beaurepaire, Tiago de Oliveira, Johnny Gasperi, Romain Tramoy, Mohamed Saad, Bruno Tassin, Rachid Dris
Urban highways are a central infrastructure in megacities and represent diverse sources of microplastic pollution. Understanding the relative contribution of these microplastic sources, including the abrasion of macrolitter and the generation of tire and road wear particles (TRWP) is necessary to better assess the sources and fate of microplastics in terrestrial environments. This study focuses on microplastic (MP) and TRWP infiltration in the soil of a biofiltration swale alongside a high-traffic highway in the north of Paris, France. First, using manual core sampling, soil samples were collected and analysed by micro-Fourier Transformed Infrared (micro-FTIR) imaging and Pyrolysis-Gas Chromatography-Mass Spectrometry (Py-GC/MS) to determine the stock and vertical distribution of microplastics and TRWP. Secondly, the relative contribution of major microplastics and TRWP sources into the soils were estimated. Finally, these field results were then used to provide an estimate of the mass balance of microplastics and TRWP on that site. Results revealed a median concentration of 5.4 μg MP g-1, three orders of magnitude lower than the median TRWP concentration of, 1.16 mg TRWP g-1. In both types of contaminations, surface samples presented a significantly higher microplastic abundance than deeper layers, with 90% of the overall stock located in the surface layers. The major contributors to microplastics accumulation in the soils were found to be fragmentation of macrolitter found on-site, followed by road runoff. The TRWP accumulation on-site was significantly lower than the TRWP production from the local traffic, suggesting TRWP may either remain trapped in the road or are deposited away from the road. To better understand the distance around a road that is affected by TRWP and microplastic emissions, further studies should be conducted at varying distances around highways. The present study focusing on a site highly exposed to microplastic and TRWP pollution helps prioritize the sources and improves the understanding of the short scale transfer dynamics of the plastic pollution stemming from an urban road.
{"title":"Stock and vertical distribution of microplastics and tire and road wear particles into the soils of a high-traffic roadside biofiltration swale","authors":"Max Beaurepaire, Tiago de Oliveira, Johnny Gasperi, Romain Tramoy, Mohamed Saad, Bruno Tassin, Rachid Dris","doi":"10.1016/j.envpol.2025.126092","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126092","url":null,"abstract":"Urban highways are a central infrastructure in megacities and represent diverse sources of microplastic pollution. Understanding the relative contribution of these microplastic sources, including the abrasion of macrolitter and the generation of tire and road wear particles (TRWP) is necessary to better assess the sources and fate of microplastics in terrestrial environments. This study focuses on microplastic (MP) and TRWP infiltration in the soil of a biofiltration swale alongside a high-traffic highway in the north of Paris, France. First, using manual core sampling, soil samples were collected and analysed by micro-Fourier Transformed Infrared (micro-FTIR) imaging and Pyrolysis-Gas Chromatography-Mass Spectrometry (Py-GC/MS) to determine the stock and vertical distribution of microplastics and TRWP. Secondly, the relative contribution of major microplastics and TRWP sources into the soils were estimated. Finally, these field results were then used to provide an estimate of the mass balance of microplastics and TRWP on that site. Results revealed a median concentration of 5.4 μg MP g<sup>-1</sup>, three orders of magnitude lower than the median TRWP concentration of, 1.16 mg TRWP g<sup>-1</sup>. In both types of contaminations, surface samples presented a significantly higher microplastic abundance than deeper layers, with 90% of the overall stock located in the surface layers. The major contributors to microplastics accumulation in the soils were found to be fragmentation of macrolitter found on-site, followed by road runoff. The TRWP accumulation on-site was significantly lower than the TRWP production from the local traffic, suggesting TRWP may either remain trapped in the road or are deposited away from the road. To better understand the distance around a road that is affected by TRWP and microplastic emissions, further studies should be conducted at varying distances around highways. The present study focusing on a site highly exposed to microplastic and TRWP pollution helps prioritize the sources and improves the understanding of the short scale transfer dynamics of the plastic pollution stemming from an urban road.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"56 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.envpol.2025.126103
Lan Zhang, Xiuxiu Ma, Tong Su, Yue Wang, Miaomiao Hai, Feifei Qi, Le Ma, Shunming Zhang, Jing Lin
The fluctuation of endocrine hormones during early pregnancy plays an important role in the pathogenesis of hyperemesis gravidarum (HG). As an endocrine disrupting chemical (EDC), perfluoroalkyl substances (PFASs) exert an impact on pregnancy-related complications by altering hormone balances throughout gestation. Despite this potential impact, the relationship between serum PFAS levels in early pregnancy and the risk of HG has not been previously investigated. A total of 98 HG cases and 495 controls were included in this study from the Xi'an Birth Cohort Study. In total, serum levels of 10 PFASs were measured using High Performance Liquid Chromatography with tandem Mass Spectrometry (HPLC-MS/MS) during early pregnancy. Binary logistic models were applied to evaluate the associations between individual PFAS levels and HG. Weighted quantile sum (WQS) regression models and Bayesian kernel machine regression (BKMR) models were performed to test the overall effect of the PFAS mixture on HG. After adjusting for confounding variables, the highest tertile concentrations of perfluoroundecanoic acid (PFUnDA) (OR: 3.49, 95%CI: 1.31-9.29), and perfluorododecanoic acid (PFDoA) (OR: 3.13, 95% CI: 1.40-6.98) were significantly associated with a higher risk of HG, while highest tertile of perfluorohexanoic acid (PFHxA) (OR: 0.34; 95% CI: 0.16-0.73), and PFOS (OR: 0.35; 95% CI: 0.13-0.97) were inversely associated with HG. The WQS index showed a positive correlation with HG risk (β= 0.80; 95% CI: 0.02, 1.57), with notable contributions from PFDoA (0.952), PFUnDA (0.159), and perfluorobutanoic acid (PFBA) (0.146). In addition, the joint effect of the PFAS mixture was positively associated with HG, with PFDoA (posterior inclusion probability (PIP)=0.78) and PFUnDA (PIP=0.75) being identified as the primary contributors. Our findings indicate that exposure to PFAS mixture during early pregnancy was associated with an increased risk of HG, with PFDoA and PFUnDA being the major contributors.
{"title":"Association between exposure to perfluoroalkyl substances (PFASs) and risk of hyperemesis gravidarum","authors":"Lan Zhang, Xiuxiu Ma, Tong Su, Yue Wang, Miaomiao Hai, Feifei Qi, Le Ma, Shunming Zhang, Jing Lin","doi":"10.1016/j.envpol.2025.126103","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126103","url":null,"abstract":"The fluctuation of endocrine hormones during early pregnancy plays an important role in the pathogenesis of hyperemesis gravidarum (HG). As an endocrine disrupting chemical (EDC), perfluoroalkyl substances (PFASs) exert an impact on pregnancy-related complications by altering hormone balances throughout gestation. Despite this potential impact, the relationship between serum PFAS levels in early pregnancy and the risk of HG has not been previously investigated. A total of 98 HG cases and 495 controls were included in this study from the Xi'an Birth Cohort Study. In total, serum levels of 10 PFASs were measured using High Performance Liquid Chromatography with tandem Mass Spectrometry (HPLC-MS/MS) during early pregnancy. Binary logistic models were applied to evaluate the associations between individual PFAS levels and HG. Weighted quantile sum (WQS) regression models and Bayesian kernel machine regression (BKMR) models were performed to test the overall effect of the PFAS mixture on HG. After adjusting for confounding variables, the highest tertile concentrations of perfluoroundecanoic acid (PFUnDA) (OR: 3.49, 95%CI: 1.31-9.29), and perfluorododecanoic acid (PFDoA) (OR: 3.13, 95% CI: 1.40-6.98) were significantly associated with a higher risk of HG, while highest tertile of perfluorohexanoic acid (PFHxA) (OR: 0.34; 95% CI: 0.16-0.73), and PFOS (OR: 0.35; 95% CI: 0.13-0.97) were inversely associated with HG. The WQS index showed a positive correlation with HG risk (<em>β</em>= 0.80; 95% CI: 0.02, 1.57), with notable contributions from PFDoA (0.952), PFUnDA (0.159), and perfluorobutanoic acid (PFBA) (0.146). In addition, the joint effect of the PFAS mixture was positively associated with HG, with PFDoA (posterior inclusion probability (PIP)=0.78) and PFUnDA (PIP=0.75) being identified as the primary contributors. Our findings indicate that exposure to PFAS mixture during early pregnancy was associated with an increased risk of HG, with PFDoA and PFUnDA being the major contributors.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"34 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The persistent organic pollutant perfluorooctane sulfonate (PFOS) is demonstrated to induce hepatotoxicity through disrupting iron homeostasis and subsequent ferroptosis in hepatocytes. However, it is still elusive in the mechanisms underneath the dysfunctional iron metabolism caused by PFOS. In this study, we observed that PFOS activated the nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy in mice liver and human hepatocytes. PFOS reduced the ubiquitination of NCOA4, subsequently causing an increase in the expression of NCOA4. PFOS induced the ubiquitination of HECT and RLD domain-containing E3 ubiquitin protein ligase 2 (HERC2), an upstream negative regulator of NCOA4, leading to the degradation of HERC2. PFOS upregulated the level of detyrosinated α-tubulin (detyr-α-tubulin) in hepatocytes. Under PFOS exposure, detyr-α-tubulin interacted with tripartite motif containing 21 (TRIM21), another E3 ubiquitin ligase responsible for HERC2 degradation. Despite the reduction in the protein level of HERC2, the increases in detyr-α-tubulin and the interaction between detyr-α-tubulin and TRIM21 caused by PFOS facilitated the interaction between TRIM21 and HERC2. Furthermore, inhibiting α-tubulin detyrosination by parthenolide reversed the ferritinophagy and the following ferroptosis caused by PFOS. Collectively, this study points out the existence of ferritinophagy and enriches the understanding of the alteration in iron metabolism under PFOS exposure, providing novel mechanistic insights into the hepatic toxicity of PFOS.
{"title":"Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes","authors":"Ruzhen Feng, Lingli Hu, Wei Yang, Peiyao Liang, Yu Li, Kefan Tian, Kejing Wang, Tianming Qiu, Jingyuan Zhang, Xiance Sun, Xiaofeng Yao","doi":"10.1016/j.envpol.2025.126101","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126101","url":null,"abstract":"The persistent organic pollutant perfluorooctane sulfonate (PFOS) is demonstrated to induce hepatotoxicity through disrupting iron homeostasis and subsequent ferroptosis in hepatocytes. However, it is still elusive in the mechanisms underneath the dysfunctional iron metabolism caused by PFOS. In this study, we observed that PFOS activated the nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy in mice liver and human hepatocytes. PFOS reduced the ubiquitination of NCOA4, subsequently causing an increase in the expression of NCOA4. PFOS induced the ubiquitination of HECT and RLD domain-containing E3 ubiquitin protein ligase 2 (HERC2), an upstream negative regulator of NCOA4, leading to the degradation of HERC2. PFOS upregulated the level of detyrosinated α-tubulin (detyr-α-tubulin) in hepatocytes. Under PFOS exposure, detyr-α-tubulin interacted with tripartite motif containing 21 (TRIM21), another E3 ubiquitin ligase responsible for HERC2 degradation. Despite the reduction in the protein level of HERC2, the increases in detyr-α-tubulin and the interaction between detyr-α-tubulin and TRIM21 caused by PFOS facilitated the interaction between TRIM21 and HERC2. Furthermore, inhibiting α-tubulin detyrosination by parthenolide reversed the ferritinophagy and the following ferroptosis caused by PFOS. Collectively, this study points out the existence of ferritinophagy and enriches the understanding of the alteration in iron metabolism under PFOS exposure, providing novel mechanistic insights into the hepatic toxicity of PFOS.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"56 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clean Air Actions were implemented in China in 2013 to reduce air pollutants in the atmosphere through stringent emission controls. Alkylated polycyclic aromatic hydrocarbons (Alk-PAHs), which are derivatives of polycyclic aromatic hydrocarbons, are highly toxic, and their levels have been affected after the implementation. This study—conducted in Harbin, a northeastern Chinese city—investigated the policy’s impact by analyzing temporal variations in the concentrations of gaseous and particulate Alk-PAHs from 2014 to 2019. The major air-pollutant data were obtained from the China National Environmental Monitoring Center Network. The measured concentrations of Alk-PAHs in the atmosphere exhibited a significant decreasing trend, with a halving time of 2.67 ± 0.63 years. Meanwhile, the cancer risk (CR) associated with inhalation and dermal exposure demonstrated a halving time of 1.80 ± 0.49 years. Despite the declining trends in the CR associated with inhalation and dermal exposure across three age groups (children, adolescents, and adults), adolescents showed a potential CR. Furthermore, by differentiating the effects of meteorological factors and anthropogenic emission control measures on the decreasing concentrations of ∑30Alk-PAHs and total benz[a]pyrene equivalent concentration (∑BaPeq), 64% of the reduction in the concentration of ∑30Alk-PAHs and 87% of the decline in ∑BaPeq was attributed to anthropogenic emission control measures. Therefore, we can deduce that the implementation of Clean Air Actions not only decreased the concentrations of primary air pollutants, such as PM2.5 particles, PM10 particles, sulfur dioxide, nitrogen oxides, and carbon monoxide but also decreased the concentration of atmospheric Alk-PAHs.
{"title":"Proof of effect from Clean Air Actions on atmospheric alkylated polycyclic aromatic hydrocarbons","authors":"Lifu Wang, Mingchao Wang, Longze Qu, Zhineng Wu, Gengbo Ren, Jiao Wang, Xiaodong Ma","doi":"10.1016/j.envpol.2025.126098","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126098","url":null,"abstract":"Clean Air Actions were implemented in China in 2013 to reduce air pollutants in the atmosphere through stringent emission controls. Alkylated polycyclic aromatic hydrocarbons (Alk-PAHs), which are derivatives of polycyclic aromatic hydrocarbons, are highly toxic, and their levels have been affected after the implementation. This study—conducted in Harbin, a northeastern Chinese city—investigated the policy’s impact by analyzing temporal variations in the concentrations of gaseous and particulate Alk-PAHs from 2014 to 2019. The major air-pollutant data were obtained from the China National Environmental Monitoring Center Network. The measured concentrations of Alk-PAHs in the atmosphere exhibited a significant decreasing trend, with a halving time of 2.67 ± 0.63 years. Meanwhile, the cancer risk (CR) associated with inhalation and dermal exposure demonstrated a halving time of 1.80 ± 0.49 years. Despite the declining trends in the CR associated with inhalation and dermal exposure across three age groups (children, adolescents, and adults), adolescents showed a potential CR. Furthermore, by differentiating the effects of meteorological factors and anthropogenic emission control measures on the decreasing concentrations of ∑<sub>30</sub>Alk-PAHs and total benz[<em>a</em>]pyrene equivalent concentration (∑<em>BaP</em><sub>eq</sub>), 64% of the reduction in the concentration of ∑<sub>30</sub>Alk-PAHs and 87% of the decline in ∑<em>BaP</em><sub>eq</sub> was attributed to anthropogenic emission control measures. Therefore, we can deduce that the implementation of Clean Air Actions not only decreased the concentrations of primary air pollutants, such as PM<sub>2.5</sub> particles, PM<sub>10</sub> particles, sulfur dioxide, nitrogen oxides, and carbon monoxide but also decreased the concentration of atmospheric Alk-PAHs.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"26 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-20DOI: 10.1016/j.envpol.2025.126105
Zara L.R. Botterell, Rachel L. Coppock, Alessio Gomiero, Penelope K. Lindeque, Stefania Piarulli, Thomas Rees, Lisbet Sørensen, Matthew Cole
Microplastics are a prolific environmental contaminant that pose a risk to marine organisms. Ecotoxicological studies have identified microplastics can cause sub-lethal harm to aquatic biota. However, prior studies often lack comparability and environmental relevance, for example focussing upon monodisperse beads at extremely high concentrations. Copepods are keystone marine taxa that play vital roles in the marine food web and biogeochemical cycling. In this study, we adapted ISO methods to conduct acute and partial life-cycle toxicity tests exposing adult and juvenile life stages of the copepod Acartia tonsa to a fully characterised tri-polymer microplastic blend comprising cryoground polyethylene, polypropylene, and nylon particles (5-100 μm) at concentrations ranging 0-1000 μg L-1. The tests considered the toxicity of microplastics on a wide number of endpoints including adult survival, algal ingestion rates, egg production and size, larval development ratio and juvenile survival. Mortality, egg size and larval development ratio proved to be the most sensitive endpoints. The tri-polymer blend had an LC5072h value of 182 μg L-1 providing a baseline for future toxicity testing using this method.
{"title":"Acute and partial life-cycle toxicity of a tri-polymer blend of microplastics in the copepod Acartia tonsa","authors":"Zara L.R. Botterell, Rachel L. Coppock, Alessio Gomiero, Penelope K. Lindeque, Stefania Piarulli, Thomas Rees, Lisbet Sørensen, Matthew Cole","doi":"10.1016/j.envpol.2025.126105","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126105","url":null,"abstract":"Microplastics are a prolific environmental contaminant that pose a risk to marine organisms. Ecotoxicological studies have identified microplastics can cause sub-lethal harm to aquatic biota. However, prior studies often lack comparability and environmental relevance, for example focussing upon monodisperse beads at extremely high concentrations. Copepods are keystone marine taxa that play vital roles in the marine food web and biogeochemical cycling. In this study, we adapted ISO methods to conduct acute and partial life-cycle toxicity tests exposing adult and juvenile life stages of the copepod <em>Acartia tonsa</em> to a fully characterised tri-polymer microplastic blend comprising cryoground polyethylene, polypropylene, and nylon particles (5-100 μm) at concentrations ranging 0-1000 μg L<sup>-1</sup>. The tests considered the toxicity of microplastics on a wide number of endpoints including adult survival, algal ingestion rates, egg production and size, larval development ratio and juvenile survival. Mortality, egg size and larval development ratio proved to be the most sensitive endpoints. The tri-polymer blend had an LC50<sub>72h</sub> value of 182 μg L<sup>-1</sup> providing a baseline for future toxicity testing using this method.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"56 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mangrove-settled spiders play a crucial role in maintaining the ecological balance of mangrove wetlands, yet organohalogen contaminants (OHCs) pose a significant threat to these species. This study evaluated the dietary composition (including 15 insect species) and OHC accumulation in Nephila pilipes, a dominant spider species, across two mangrove habitats, using data from 80 OHCs and quantitative fatty acid signature analysis (QFASA). Dichlorodiphenyltrichloroethane (DDT) accounted for over 50% of the total OHCs in both spiders and insects, followed by polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), alternative halogenated flame retardants (AHFRs), and hexachlorocyclohexane (HCHs). Biomagnification and trophic magnification patterns of OHCs were consistent across both mangroves, suggesting that spatial variability did not significantly influence overall biomagnification. Carnivorous insects exhibited lower proportions of tetra- and penta-BDEs compared to phytophagous insects but had significantly higher total OHC concentrations. The presence of carnivorous insects, such as the ditch jewel, in the spider diet was negatively correlated with phytophagous insects, such as the common emigrant and tobacco cutworm, suggesting potential niche exclusivity. Spiders from more polluted mangroves accumulated higher OHC concentrations, with carnivorous insects contributing 64.9 ± 3.90% and 67.9 ± 5.79% to the total OHC load in Zhuhai and Shenzhen, respectively. The regional differences in OHC concentrations were primarily attributed to higher background pollution levels in Shenzhen rather than dietary composition alone. This study highlights the influence of regional pollution on OHC accumulation in mangrove spiders and underscores the importance of region-specific dietary assessments for accurate pollutant bioaccumulation evaluations.
{"title":"Regional pollution and diet drive organohalogen contaminant accumulation in mangrove-settled spiders (Nephila pilipes)","authors":"Qiang Xie, Lihua Yang, Lvyan Tan, Fenglong Jia, Shuang Zhao, Yuhai Lu, Yuping Wu, Li Lin, Tiangang Luan","doi":"10.1016/j.envpol.2025.126100","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126100","url":null,"abstract":"Mangrove-settled spiders play a crucial role in maintaining the ecological balance of mangrove wetlands, yet organohalogen contaminants (OHCs) pose a significant threat to these species. This study evaluated the dietary composition (including 15 insect species) and OHC accumulation in <em>Nephila pilipes</em>, a dominant spider species, across two mangrove habitats, using data from 80 OHCs and quantitative fatty acid signature analysis (QFASA). Dichlorodiphenyltrichloroethane (DDT) accounted for over 50% of the total OHCs in both spiders and insects, followed by polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), alternative halogenated flame retardants (AHFRs), and hexachlorocyclohexane (HCHs). Biomagnification and trophic magnification patterns of OHCs were consistent across both mangroves, suggesting that spatial variability did not significantly influence overall biomagnification. Carnivorous insects exhibited lower proportions of tetra- and penta-BDEs compared to phytophagous insects but had significantly higher total OHC concentrations. The presence of carnivorous insects, such as the ditch jewel, in the spider diet was negatively correlated with phytophagous insects, such as the common emigrant and tobacco cutworm, suggesting potential niche exclusivity. Spiders from more polluted mangroves accumulated higher OHC concentrations, with carnivorous insects contributing 64.9 ± 3.90% and 67.9 ± 5.79% to the total OHC load in Zhuhai and Shenzhen, respectively. The regional differences in OHC concentrations were primarily attributed to higher background pollution levels in Shenzhen rather than dietary composition alone. This study highlights the influence of regional pollution on OHC accumulation in mangrove spiders and underscores the importance of region-specific dietary assessments for accurate pollutant bioaccumulation evaluations.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"201 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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