Visible-Light-Induced Three-Component Radical Strategy for the Synthesis of β-Amino Alcohols

Abstract

This study presents a visible-light-mediated three-component radical reaction involving alcohols or alkanes and in situ-formed imines. The imines, generated from aldehydes and amines, serve as key reactants, while the inexpensive and readily available sodium decatungstate (NaDT) is employed as a photocatalyst. This strategy enables the functionalization of industrially accessible alcohols or alkanes to synthesize β-amino alcohols via an intermolecular hydrogen atom transfer (HAT) mechanism under visible-light irradiation. The reaction is operationally simple, exhibits high conversion efficiency, facilitates straightforward post-reaction processing, and demonstrates excellent atom and step economy.