{"title":"Palladium-Catalyzed Carbonylative Cyclization of Propargyl Alcohols with CO2: a Straightforward Route to Butenolides","authors":"Chaorong Qi, Zhongrong Xu, Jiecheng Huang, Ting Zhao, Yanwei Ren, Huanfeng Jiang","doi":"10.1002/adsc.202500201","DOIUrl":null,"url":null,"abstract":"A palladium-catalyzed carbonylative cyclization of propargyl alcohol with carbon dioxide (CO2) as a carbonyl source has been reported for the first time, which provides an efficient and straightforward route to a range of valuable butenolides in moderate to high yields. The reaction can be performed in one step and features good functional group tolerance and broad substrate scope. The application of the new method was also demonstrated by direct carbonylative cyclization of biologically active molecules.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"41 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202500201","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A palladium-catalyzed carbonylative cyclization of propargyl alcohol with carbon dioxide (CO2) as a carbonyl source has been reported for the first time, which provides an efficient and straightforward route to a range of valuable butenolides in moderate to high yields. The reaction can be performed in one step and features good functional group tolerance and broad substrate scope. The application of the new method was also demonstrated by direct carbonylative cyclization of biologically active molecules.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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