Exploring the interaction between ambient air pollution and road traffic noise on stroke incidence in ten Nordic cohorts

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environment International Pub Date : 2025-03-21 DOI:10.1016/j.envint.2025.109403

Huyen Nguyen Thi Khanh, Massimo Stafoggia, Mette Sørensen, Aslak Harbo Poulsen, Ole Raaschou-Nielsen, Jibran Khan, Jørgen Brandt, Anja Olsen, Zorana Jovanovic Andersen, Mette Kildevaeld Simonsen, Youn-Hee Lim, Jiawei Zhang, Thomas Cole-Hunter, Göran Pershagen, Andrei Pyko, Agneta Åkesson, Leonard Stockfelt, Eva M. Andersson, Mikael Ögren, David Segersson, Jeroen de Bont

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引用次数: 0

Abstract

Introduction

Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales.

Methods

We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finland. We modelled annual average levels of outdoor particulate matter < 2.5 µm (PM_2.5), nitrogen dioxide (NO₂) and road traffic noise at residential addresses. We applied Cox proportional hazards regression to evaluate their single association. We assessed multiplicative interaction with interaction terms in Cox models and additive interaction using the Relative Excess Risk due to Interaction method.

Results

We followed 136,897 adults for 20 years, and 8.0 % experienced stroke incidence. PM_2.5, NO₂ and road traffic noise were associated with higher stroke risk in single-exposure models. Multiplicative models showed higher HRs between PM_2.5 and stroke at higher levels of noise and vice versa: HRs per 5 μg/m³ of PM_2.5 were 1.06 (95 % CI:0.94–1.21) at 40 dB and 1.11 (95 % CI:0.85–1.44) at 80 dB of road traffic noise; HRs per 12 dB of road traffic noise were 1.06 (95 % CI:1.01–1.11) at 4 μg/m³ and 1.17 (95 % CI:0.82–1.68) at 48 μg/m³ of PM_2.5. Additive models showed that the combined association of PM_2.5 and road traffic noise was 4 % (RERI = 0.04 (95 % CI:-0.05;1.12)) higher than the sum of their individual association.

Conclusion

PM_2.5 and road traffic noise showed a non-significant synergistic association on stroke incidence.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.