{"title":"Unraveling the Heterogeneity of Asthma: Decoding Subtypes of Asthma.","authors":"Anne L Fuhlbrigge, Sunita Sharma","doi":"10.1016/j.jaci.2025.03.008","DOIUrl":null,"url":null,"abstract":"<p><p>Asthma is a heterogeneous disease with diverse underlying mechanisms contributing to disease susceptibility and progression. Asthma endotypes and phenotypes have emerged as critical frameworks to help understand the variation in disease presentation and response to therapies. Phenotypes are the observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment. Asthma endotypes are distinct subsets of asthma that are characterized by specific biological pathways, including differences in inflammatory pathways, genetic predisposition, and immune response. Identifying asthma endotypes and the associated clinical phenotypes are pivotal for the development of personalized treatment strategies, as it enables clinicians to select more effective therapies based on specific biological mechanisms. This review explores asthma endotypes and their associated phenotypes and the ongoing effort to refine diagnostic tools and therapeutic personalized approaches, aiming to improve outcomes for patients with asthma.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Allergy and Clinical Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jaci.2025.03.008","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Asthma is a heterogeneous disease with diverse underlying mechanisms contributing to disease susceptibility and progression. Asthma endotypes and phenotypes have emerged as critical frameworks to help understand the variation in disease presentation and response to therapies. Phenotypes are the observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment. Asthma endotypes are distinct subsets of asthma that are characterized by specific biological pathways, including differences in inflammatory pathways, genetic predisposition, and immune response. Identifying asthma endotypes and the associated clinical phenotypes are pivotal for the development of personalized treatment strategies, as it enables clinicians to select more effective therapies based on specific biological mechanisms. This review explores asthma endotypes and their associated phenotypes and the ongoing effort to refine diagnostic tools and therapeutic personalized approaches, aiming to improve outcomes for patients with asthma.
期刊介绍：
The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.
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