[Dengue treatments and vaccines].

IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL M S-medecine Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-21 DOI:10.1051/medsci/2025025
Lazare Brézillon-Dubus, Benjamin Dupuis, Anna-Bella Failloux
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Abstract

Dengue fever is a viral disease transmitted by mosquitoes of the Aedes genus, whose incidence and range have been steadily increasing in recent decades. Causing hemorrhagic fever in severe cases, it affects the inter-tropical regions of the world and threatens to spread to new geographical areas. Its complex pathophysiology and the existence of four genetically distant serotypes make vaccine development a challenge. Currently, there is no specific treatment against dengue fever and only a few vaccines are marketed or in development, with some limitations on their use. It is therefore necessary to develop new vaccines and identify new molecules with antiviral properties to reduce the economic and public health burden of this disease in endemic areas.

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[登革热治疗和疫苗]。
登革热是一种由伊蚊传播的病毒性疾病,其发病率和传播范围近几十年来一直在稳步上升。登革热在严重病例中会引起出血热,主要影响世界热带地区,并有向新的地理区域蔓延的危险。它的病理生理学非常复杂,而且存在四种基因不同的血清型,这使得疫苗的开发成为一项挑战。目前,还没有针对登革热的特效疗法,仅有几种疫苗已上市或正在开发中,其使用也受到一定限制。因此,有必要开发新疫苗并确定具有抗病毒特性的新分子,以减轻这种疾病在流行地区造成的经济和公共卫生负担。
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来源期刊
M S-medecine Sciences
M S-medecine Sciences 医学-医学:研究与实验
CiteScore
0.80
自引率
14.30%
发文量
182
审稿时长
4-8 weeks
期刊介绍: m/s offers high-quality review articles in French, covering all areas of biomedical and health research, in a monthly magazine format (10 issues / year). m/s is read by the whole French-speaking community, in France but also in Belgium, Switzerland, Canada, Morocco, Algeria, Tunisia etc. m/s is not a primary publication, and thus will not consider unpublished data. Most articles are invited by the Editors, but spontaneous proposals are welcomed. Each issue combines news and views on the most recent scientific publications, as well as broadly accessible and updated review articles on a specific topic, and essays on science and society, history of science, public health, or reactions to published articles. Each year, m/s also publishes one or two thematic issues focused on a research topic of high interest. All review articles and essays are peer-reviewed.
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