Elevated blood pressure, stroke volume, and vascular tone in young women who use oral contraception

Abstract

Use of hormonal contraception is important to consider as a risk or protective factor in the development of cardiovascular disease. Prior reports of short and long-term effects of hormonal contraception on cardiovascular disease allude to its potential for immediate and delayed cardiovascular effects, but the nature of direct early cardiovascular changes as the result of hormonal contraception use remains understudied. This cross-sectional data analysis add-on study compared differences in cardiovascular function of naturally cycling women (n = 90) and women using oral contraceptive pills (n = 35) at rest and in response to physiological breathing challenges that activated the sympathetic (paced sighing) or parasympathetic (slow paced breathing) nervous systems. Results showed women using oral contraception had elevated resting systolic blood pressure as well as increased stroke volume and shortened pulse transit time (i.e., vasoconstriction) relative to naturally cycling women. Despite resting differences, both groups responded similarly to breathing challenges. Elevated resting blood pressure and altered sympathetic control, even at preclinical levels, may increase physiological wear-and-tear, particularly if hormonal contraceptive use continues over long periods of time. These findings are particularly compelling considering the youth and health of the current sample.