Comparative analysis of recurrence rates: Day-light versus red-light photodynamic therapy in the treatment of actinic keratosis during a five-year follow-up
Peiru Wang, Yutong Yang, Yan Zhao, Yajin Cao, Zhongxia Zhou, Guolong Zhang, Linglin Zhang, Xiuli Wang
{"title":"Comparative analysis of recurrence rates: Day-light versus red-light photodynamic therapy in the treatment of actinic keratosis during a five-year follow-up","authors":"Peiru Wang, Yutong Yang, Yan Zhao, Yajin Cao, Zhongxia Zhou, Guolong Zhang, Linglin Zhang, Xiuli Wang","doi":"10.1016/j.pdpdt.2025.104562","DOIUrl":null,"url":null,"abstract":"<div><h3>Significance</h3><div>Day-light photodynamic therapy (DL-PDT) was proved to be effective, better tolerated and nearly painless compared with red-light photodynamic therapy (RL-PDT) in actinic keratosis (AK) patients in China. But no study has compared the recurrence rates of these two methods.</div></div><div><h3>Approach</h3><div>A prospective cohort study was conducted to compare the recurrence rate of DL-PDT and RL-PDT during a five-year follow-up.</div></div><div><h3>Results</h3><div>A total of 55 patients were finally included, with 24 patients in the DL-PDT group and 31 patients in the RL-PDT group. The overall recurrence rate in the DL-PDT group was significantly higher than that in the RL-PDT group (62.50 % vs. 9.68 %, P<0.05).</div></div><div><h3>Conclusions</h3><div>The recurrence rate of DL-PDT was significantly higher than that of RL-PDT.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104562"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025000912","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Significance
Day-light photodynamic therapy (DL-PDT) was proved to be effective, better tolerated and nearly painless compared with red-light photodynamic therapy (RL-PDT) in actinic keratosis (AK) patients in China. But no study has compared the recurrence rates of these two methods.
Approach
A prospective cohort study was conducted to compare the recurrence rate of DL-PDT and RL-PDT during a five-year follow-up.
Results
A total of 55 patients were finally included, with 24 patients in the DL-PDT group and 31 patients in the RL-PDT group. The overall recurrence rate in the DL-PDT group was significantly higher than that in the RL-PDT group (62.50 % vs. 9.68 %, P<0.05).
Conclusions
The recurrence rate of DL-PDT was significantly higher than that of RL-PDT.
意义：在中国，与红光光动力治疗（RL-PDT）相比，日光光动力治疗（DL-PDT）在光化性角化病（AK）患者中被证明是有效的，耐受性更好，几乎无痛。但没有研究比较过这两种方法的复发率。方法：进行前瞻性队列研究，比较DL-PDT和RL-PDT在五年随访期间的复发率。结果：最终纳入55例患者，DL-PDT组24例，RL-PDT组31例。DL-PDT组的总复发率明显高于RL-PDT组（62.50% vs. 9.68%）。结论：DL-PDT的复发率明显高于RL-PDT。
期刊介绍：
Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
