A copper-catalyzed synthesis of benzo[4,5]imidazo[1,2-a]pyridine derivatives via C–N bond formation of 2-aminopyridines with arylboronic acids

Abstract

An innovative and efficient catalytic system was successfully constructed, and the accurate synthesis of benzo[4,5]imidazo[1,2-a]pyridines was realized through the coupling reaction of aminopyridine and arylboronic acid in the presence of copper (II) acetate catalyst with 4-OH TEMPO as oxidant. The present methodology offers several advantages such as high yields, shorter reaction times, easy work-up process, and mild reaction conditions.