Cysteine-rich intestinal protein family: structural overview, functional diversity, and roles in human disease.

IF 7 2区 生物学 Q1 CELL BIOLOGY Cell Death Discovery Pub Date : 2025-03-21 DOI:10.1038/s41420-025-02395-y
Xilin Ye, Qianben Song, Lumiao Zhang, Mengjia Jing, Yu Fu, Wei Yan
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Abstract

The cysteine-rich intestinal protein (CRIP) family, including CRIP1, CRIP2, and CRIP3, is a subfamily of the highly conserved Lin-1, Isl1, Mec3/double zinc finger protein family that exhibits diverse biological functions. The CRIP family is known to play an important role in cellular epithelial-mesenchymal transition, cell death, and tumor progression and participate in multiple signaling pathways. This article summarizes the roles and potential molecular mechanisms of the CRIP family in diseases, which will help to explore new research directions for this family and provide useful information for clinical applications such as disease diagnosis and treatment.

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富含半胱氨酸的肠道蛋白家族:结构概述、功能多样性和在人类疾病中的作用。
富含半胱氨酸的肠道蛋白(CRIP)家族包括CRIP1、CRIP2和CRIP3,是高度保守的Lin-1、Isl1、Mec3/双锌指蛋白家族的一个亚家族,具有多种生物学功能。已知CRIP家族在细胞上皮-间质转化、细胞死亡和肿瘤进展中发挥重要作用,并参与多种信号通路。本文综述了CRIP家族在疾病中的作用和潜在的分子机制,有助于探索该家族新的研究方向,为疾病诊断和治疗等临床应用提供有用的信息。
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来源期刊
Cell Death Discovery
Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
8.30
自引率
1.40%
发文量
468
审稿时长
9 weeks
期刊介绍: Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
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