The controversial role of CD151 in different solid tumors: promoter or suppressor?

IF 6 2区医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2025-03-21 DOI:10.1186/s12935-025-03751-9

Xue Gao, Sa Liu, Yubo Cao, Lei Shi, Yuanqin Yin

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Abstract

As a member of the tetraspanin superfamily, CD151 plays a pivotal role in tumorigenesis, progression, and metastasis. CD151 is involved in various cellular processes, including cell-cell junction, signal transduction, epithelial-mesenchymal transition (EMT), cancer stem cell maintenance (CSCs), angiogenesis, and exosome regulation. Therefore, CD151 is a potential target for tumor therapy and may be valuable in tumor diagnosis and prognosis. Notably, while CD151 predominantly functions as an oncogene in most cancers, it can also exhibit tumor-suppressive roles in specific contexts, indicating that its function is context-dependent. Additionally, CD151 plays a significant role in modulating the immune microenvironment. For instance, CD151 supports the proliferation, activation, and migration of T cells. The CD151 peptide may function as a tumor vaccination by stimulating CD8 + IFNγ + lymphocytes and inducing cytotoxic effects. Thus, the function of CD151 in tumors is intricate and warrants further investigation. In this review, we discuss the diagnostic and prognostic potential of CD151, as well as its regulatory roles in solid cancers, including those of the digestive system, lung, breast, prostate, and gynecological tissues. Basic experiments and clinical data demonstrate the beneficial and detrimental effects of CD151 in malignancies and offer a path forward for future investigation.

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CD151在不同实体肿瘤中的争议作用：启动子还是抑制子？

作为四联蛋白超家族的一员，CD151在肿瘤发生、进展和转移中起着关键作用。CD151参与多种细胞过程，包括细胞-细胞连接、信号转导、上皮-间充质转化（EMT）、癌症干细胞维持（CSCs）、血管生成和外泌体调节。因此，CD151是肿瘤治疗的潜在靶点，在肿瘤诊断和预后方面可能有价值。值得注意的是，虽然CD151在大多数癌症中主要作为癌基因发挥作用，但它也可以在特定环境中表现出肿瘤抑制作用，这表明它的功能依赖于环境。此外，CD151在调节免疫微环境中起着重要作用。例如，CD151支持T细胞的增殖、激活和迁移。CD151肽可能通过刺激CD8 + IFNγ +淋巴细胞和诱导细胞毒性作用而发挥肿瘤疫苗的作用。因此，CD151在肿瘤中的功能是复杂的，值得进一步研究。在这篇综述中，我们讨论了CD151的诊断和预后潜力，以及它在实体癌症中的调节作用，包括消化系统、肺、乳腺、前列腺和妇科组织。基础实验和临床数据证明了CD151在恶性肿瘤中的有益和有害作用，并为未来的研究提供了一条前进的道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.