Alexandre Pierret , Kevin Magra , Hugo Lopez , Thomas Kauffmann , Clément Denhez , Ibrahim Abdellah , Christophe Werlé , Alexandre Vasseur
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引用次数: 0
Abstract
We present a lithium zincate-enabled, divergent one-pot synthesis for regioselective dual C–C bond formation in thiophenes. By modifying the zinc coordination environment, a single set of reagents (ZnCl2, R1Li, and diethyl (5-halo)thenylphosphate) was found to generate two distinct products. This approach extends the versatility of lithium organozincates to regioselective CAr(sp2)–Cthienyl(sp2) and Cthenyl(sp3)–CAr(sp2) couplings without requiring transition metals and/or arenes pre-activated with a boronic acid.
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