Three new polyketide metabolites from the endophytic fungus Trichoderma protrudens of Hibiscus tiliaceus

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI:10.1016/j.phytol.2025.102950

Yan-Mei Wu , Jing-Ya Mo , Yong-Yan Mei , Quan Liu , Yuan-Yuan Huang , Bei Zhou , Yi-Hang Li , Yan-Chun Wu , Jing-Quan Yuan

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Abstract

Trichodones D-F (1-3), three previously undescribed polyketide compounds featuring conjugated α-β-unsaturated ketone moieties, were isolated from the endophytic fungus Trichoderma protrudens associated with the semi-mangrove plant Hibiscus tiliaceus Linn. The structural elucidation of these compounds was accomplished through the analysis of 1D and 2D NMR spectra, complemented by HR-ESI-MS data. The absolute configurations were determined through comparative analysis of experimental CD and calculated ECD spectra. Additionally, the cytotoxic activities of compounds 1-3 against the human breast cancer cell line MCF-7 and the human hepatocellular carcinoma cell line HepG2 were evaluated using the CCK8 assay. Notably, compound 3 exhibited moderate inhibitory activity against HepG2 and MCF-7 cell lines with IC₅₀ values of 22.7 μM and 55.1 μM, respectively.

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木槿内生真菌突出木霉的三个新聚酮代谢物

trichodoones D-F（1-3）是从半红树林植物芙蓉（Hibiscus tiliaceus Linn）内生真菌突起木霉（Trichoderma protrudens）中分离得到的3个具有共轭α-β-不饱和酮基团的聚酮化合物。这些化合物的结构通过1D和2D NMR谱分析，并辅以HR-ESI-MS数据来完成。通过对比分析实验CD和计算ECD谱，确定了绝对构型。此外，采用CCK8法评价化合物1-3对人乳腺癌细胞系MCF-7和人肝癌细胞系HepG2的细胞毒活性。值得注意的是，化合物3对HepG2和MCF-7细胞株具有中等抑制活性，IC50值分别为22.7 μM和55.1 μM。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.