Mohd Afzal , Pronab Kundu , Abdulnasser Mahmoud Karami , Tapas Kamilya , Ali Akhtar , Mani Durai , Krishnamoorthy Shanmugaraj , Jinhyoung Park , Praveen Barmavatu , Md Kasif , Mathivanan Durai , Aniruddha Mondal , Young Ho Ahn
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引用次数: 0
Abstract
Carbon dots (CDs) have gained significant attention as a promising theranostic platform, owing to their excellent biocompatibility, tunable fluorescence, and multifunctional properties. In this work, we present the development of highly luminescent CDs synthesized from natural precursors, engineered to serve as a versatile nanoplatform for nitric oxide (NO) delivery. By functionalizing the surface of the CDs with ruthenium nitrosyl (Ru-NO) complexes and folic acid, we created a targeted system (CDs-FAR) that enables precise drug delivery, real-time fluorescence tracking, and light-triggered NO release. The CDs demonstrated exceptional antioxidant activity, with scavenging efficiencies of ∼77 % and ∼89 % in 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays, respectively, underscoring their potential for oxidative stress regulation. Furthermore, controlled NO release was achieved under light irradiation (100–300 mW/cm2), highlighting the system's ability to respond to external stimuli for accurate therapeutic action. This multifunctional platform holds great potential for treating disorders related to nitric oxide deficiency and advancing NO-based cancer therapies, offering a novel approach in the fields of precision medicine and nano-theranostics.
期刊介绍：
DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices.
The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.
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