Therapeutic potential of Phoenix dactylifera pulp and seed extracts in mitigating oxidative stress and organ dysfunction in testosterone-induced polycystic ovary syndrome

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Journal of Functional Foods Pub Date : 2025-03-22 DOI:10.1016/j.jff.2025.106743

Maryam Sana , Muhammad Arshad , Farzana Siddique , Hafiz Muhammad Irfan , Mulazim Hussain Asim , Waseem Khalid , Robert Mugabi , Tawfiq Alsulami , Gulzar Ahmad Nayik

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Abstract

Polycystic ovary syndrome is associated with metabolic disorders, infertility and chronic diseases. Dietary nutrients playing vital role, Ajwa dates (Phoenix Dactylifera) known for exceptional nutritional and therapeutic properties, were tested as an alternative to polypharmacy. The aim was to explore the potential reversibility of oxidative stress and mitigate the kidney and liver damage associated with PCOS. PCOS was induced through testosterone enanthate (1.0 mg/100 g/BW) injection for 35-days. Ajwa whole date and seed extracts (500, 1000, and 2000 mg/kgBW) administered for 28 days, alongside metformin (250 mg/kgBW). Phytochemical profiling was conducted using HPLC and FTIR techniques. The results, revealing the effects of treatments, exposure duration, and their interactions in groups treated with metformin and Ajwa dates. Their treatment showed significant improvements (p < 0 0.001) in hormonal profile, liver and kidney function and oxidative stress markers compared to PCOS group. These finding highlight Ajwa dates potential as natural therapeutic option for managing PCOS and associated complications.

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凤尾草果肉和种子提取物在缓解睾丸激素诱导的多囊卵巢综合征的氧化应激和器官功能障碍中的治疗潜力

多囊卵巢综合征与代谢紊乱、不孕症和慢性疾病有关。膳食营养素起着至关重要的作用，Ajwa枣（凤凰Dactylifera）以其独特的营养和治疗特性而闻名，被测试为多种药物的替代品。目的是探讨氧化应激的潜在可逆性，并减轻与多囊卵巢综合征相关的肾脏和肝脏损伤。注射增强睾酮（1.0 mg/100 g/BW）诱导PCOS 35 d。Ajwa全枣和种子提取物（500、1000和2000 mg/kgBW）与二甲双胍（250 mg/kgBW）一起施用28天。采用HPLC和FTIR技术进行植物化学分析。结果显示，二甲双胍和Ajwa枣组的治疗效果，暴露时间和它们的相互作用。他们的治疗有显著改善(p <；与PCOS组相比，PCOS组的激素谱、肝肾功能和氧化应激标志物的差异均为0 0.001)。这些发现突出了Ajwa日期作为治疗多囊卵巢综合征和相关并发症的天然治疗选择的潜力。

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.