{"title":"Thoracic SMARCA4-deficient undifferentiated tumor","authors":"Yukina Izumi , Yuko Sano , Kaori Yamada , Yusuke Ichijo , Mariko Yoshida , Yuka Nishioka , Natsuki Imoto , Tatsuya Imabayashi , Kazuki Jinno , Yoji Urata , Katsumi Hayakawa","doi":"10.1016/j.radcr.2025.02.109","DOIUrl":null,"url":null,"abstract":"<div><div>Thoracic <em>SMARCA4</em>-deficient undifferentiated tumor (<em>SMARCA4</em>-UT) is characterized by an undifferentiated rhabdoid morphology and <em>SMARCA4</em> deficiency pathologically. In the 2021 revision of the WHO classification, it was categorized as an epithelial tumor because of its shared genetic background with smoking-related lung cancer.</div><div>We describe the case of a 44-year-old man with a rapidly enlarging mediastinal mass observed on chest radiography and CT. The tumor was resistant to radiation therapy, chemotherapy, and immune checkpoint inhibitors, and the patient's survival time was approximately 5 months. Familiarity with the clinical background and imaging findings of thoracic <em>SMARCA4</em>-UT is crucial for early diagnosis and treatment planning.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 6","pages":"Pages 2950-2955"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1930043325002109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is characterized by an undifferentiated rhabdoid morphology and SMARCA4 deficiency pathologically. In the 2021 revision of the WHO classification, it was categorized as an epithelial tumor because of its shared genetic background with smoking-related lung cancer.
We describe the case of a 44-year-old man with a rapidly enlarging mediastinal mass observed on chest radiography and CT. The tumor was resistant to radiation therapy, chemotherapy, and immune checkpoint inhibitors, and the patient's survival time was approximately 5 months. Familiarity with the clinical background and imaging findings of thoracic SMARCA4-UT is crucial for early diagnosis and treatment planning.
期刊介绍：
The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.
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