A simple way to well-posedness in H1 of a delay differential equation from cell biology

Abstract

We present an application of recent well-posedness results in the theory of delay differential equations for ordinary differential equations [10] to a generalized population model for stem cell maturation. The weak approach using Sobolev-spaces we take allows for a larger class of initial prehistories and makes checking the requirements for well-posedness of such a model considerably easier compared to previous approaches. In fact the present approach is a possible means to guarantee that the solution manifold is not empty, which is a necessary requirement for a $C^1$-approach to work.